PLoS ONE, 2021 Challenges arise in researching health effects associated with chemical mixtures. Several methods have recently been proposed for estimating the association between health outcomes and exposure to chemical mixtures, but a formal simulation study ...
Lauren Hoskovec +4 more
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Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach [PDF]
Environment International, 2020 Background: Maternal and neonatal thyroid function is critical for growth and neurodevelopment. Exposure to individual per- and polyfluoroalkyl substances (PFAS) can alter circulating thyroid hormone levels, but few studies have investigated effects of ...
Emma V. Preston +10 more
doaj +3 more sources
Environmental Health, 2018 Background Estimating the health effects of multi-pollutant mixtures is of increasing interest in environmental epidemiology. Recently, a new approach for estimating the health effects of mixtures, Bayesian kernel machine regression (BKMR), has been ...
Jennifer F. Bobb +3 more
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Comparative efficacy of three Bayesian variable selection methods in the context of weight loss in obese women [PDF]
Frontiers in Nutrition, 2023 The use of high-dimensional data has expanded in many fields, including in clinical research, thus making variable selection methods increasingly important compared to traditional statistical approaches.
Nicola Pesenti +7 more
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Ecotoxicology and Environmental Safety, 2023 Exposure to metal mixtures may affect children's health but the conclusions are controversial. We aimed to investigate the associations of metal mixture exposure with children’s physical and behavioral development.
Jiehua Ma +8 more
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Prenatal Exposure to Chemical Mixtures and Cognitive Flexibility among Adolescents
Toxics, 2021 Cognitive flexibility, the ability to smoothly adapt to changing circumstances, is a skill that is vital to higher-level executive functions such as problem-solving, planning, and reasoning.
Anna V. Oppenheimer +4 more
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Combined Effect of Metals, PFAS, Phthalates, and Plasticizers on Cardiovascular Disease Risk
ToxicsThis study assessed the relationship between environmental chemical mixtures—including metals, per- and polyfluoroalkyl substances (PFAS), phthalates, and plasticizers—and key cardiovascular health markers using data from the 2013–2014 National Health ...
Doreen Jehu-Appiah, Emmanuel Obeng-Gyasi
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Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response [PDF]
Frontiers in EndocrinologyBackgroundTerpenes are potentially harmful substances that are associated with endocrine disruption due to their ability to produce oxidizers, aldehydes, and secondary aerosol particles.
Jiyu Nie +17 more
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Dietary Selenium and β-Carotene Contribute to the Inverse Association Between Antioxidant Mixtures and Stroke: Evidence From NHANES Using Mixture Models and Machine Learning. [PDF]
Food Sci NutrIn this NHANES study of 37,746 participants, we examined the joint association of six dietary antioxidant‐related nutrients (vitamins A, C, and E, β‐carotene, selenium, and zinc) with stroke, applying 1:1 propensity score matching (matched sub‐cohort, n = 2750), mixture models (WQS, qgcomp, and BKMR), and machine learning with SHAP interpretation ...
Zhong A +6 more
europepmc +2 more sources
An exploratory study on the association of multiple metals in serum with preeclampsia [PDF]
Frontiers in Public HealthBackgroundIndividual metal levels are potential risk factors for the development of preeclampsia (PE). However, understanding of relationship between multiple metals and PE remains elusive.PurposeThe purpose of this study was to explore whether eight ...
Jie He +7 more
doaj +2 more sources