Results 71 to 80 of about 9,092,875 (288)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Minor Miracles: Toward A Theory of Novelty in "Aya of Yopougon"

Lateral, 2017
This essay undertakes a reparative reading of Aya of Yopougon, a multivolume graphic novel by Marguerite Abouet and Clément Oubrerie. Setting Aya alongside other African comics and prevailing interpretations of African and Diasporic literatures, this ...
andré m carrington
doaj   +1 more source

Hidden Beneath: Watermarks in the Early American Document Collection [PDF]

, 2016
This summer, as the Smith Intern at Special Collections, I was tasked with working on a hodge-podge of assembled documents, previously referred to as the “18th Century Document” collection.
Black, Tyler R.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dossier: Mapping Screen Heritage (Introduction)

Alphaville: Journal of Film and Screen Media
Archives of film and media are being challenged, critiqued, and reimagined. The heritage that has been preserved and the knowledge production to which it contributes has typically reinforced systemic structural barriers and inequalities and privileged ...
Rinella Cere, James Fenwick, Danilo Giglitto   +2 more
doaj   +1 more source

“Beef Jerky in a Ball Gown”: The Camp Excesses of Titus Andromedon in Unbreakable Kimmy Schmidt

Open Cultural Studies, 2017
In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences.
Dexl Carmen, Horn Katrin
doaj   +1 more source

Centerscope [PDF]

, 1981
Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.
Black, Paul H.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mission studies at South African higher education institutions: An ethical and decolonial perspective in the quest to ‘colour’ the discipline

HTS Teologiese Studies/Theological Studies, 2020
The recent debate on decolonisation calls for all academic disciplines, including missiology modules, at public universities to reflect on its content, curriculum and pedagogies.
Eugene Baron
doaj   +1 more source

Blow-up of weak solutions to a chemotaxis system under influence of an external chemoattractant

, 2015
We study nonnnegative radially symmetric solutions of the parabolic-elliptic Keller-Segel whole space system \begin{align*} \left\{\begin{array}{c@{\,}l@{\quad}l@{\,}c} u_{t}&=\Delta u-\nabla\!\cdot(u\nabla v),\ &x\in\mathbb{R}^n,& t>0,\\ 0 &=\Delta v+u ...
Black, Tobias
core   +1 more source