Results 41 to 50 of about 561,399 (265)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Explaining any black box model using real data
Frontiers in Computer Science, 2023 In recent years the use of complex machine learning has increased drastically. These complex black box models trade interpretability for accuracy. The lack of interpretability is troubling for, e.g., socially sensitive, safety-critical, or knowledge ...
Anton Björklund +6 more
doaj +1 more source
SSRN Electronic Journal, 2013 Abstract This chapter studies strategic behavior when agents have no information about the structure of the underlying game and they cannot observe other agents’ actions or payoffs. Even when players have no such information, there are simple payoff-based learning rules that lead to Nash equilibrium in many types of games, as shown in ...
Nax, Heinrich H +3 more
openaire +8 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Natural Representations of Black Box Groups SL2
AxiomsIn this paper, we make one step further in the recognition of black box groups of Lie type: given a black box group encrypting a special linear group of dimension 2 over a finite field of an unknown odd characteristic, we construct a black box field and ...
Alexandre Borovik, Şükrü Yalçınkaya
doaj +1 more source
Parameter identification of dc black-box arc model using non-linear least squares
The Journal of Engineering, 2019 The black-box arc model is known to be a useful technique to simulate dynamic arc-circuit interaction by reflecting arc characteristics. Existing researches have shown that the black-box model has been widely used to analyse the ac arc characteristics of
Kyu-Hoon Park +3 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
VBSM: VCC-Based Black Box Service Model with Enhanced Data Integrity
Information, 2014 Recently, intelligent transport systems have been applied to vehicle cloud environments. Such technology is especially useful for the systematic management of road traffic.
Won Min Kang +2 more
doaj +1 more source