Results 61 to 70 of about 2,527,813 (283)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Opening the Leontief's black box
Heliyon, 2018 The paper attempts to reconstruct what goes on inside the black box of the fixed proportions production function underlying the matrix of technical coefficients in the famous Leontief's input–output analysis.
A. Mustafin, A. Kantarbayeva
doaj +1 more source
An ADMM Based Framework for AutoML Pipeline Configuration
, 2019 We study the AutoML problem of automatically configuring machine learning pipelines by jointly selecting algorithms and their appropriate hyper-parameters for all steps in supervised learning pipelines.
Bouneffouf, Djallel +8 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Efficient Robot Design With Multi-Objective Black-Box Optimization and Large Language Models
IEEE AccessVarious methods for robot design optimization have been developed so far. These methods are diverse, ranging from numerical optimization to black-box optimization.
Kento Kawaharazuka +4 more
doaj +1 more source
Grey Box Data Refinement [PDF]
, 1998 We introduce the concepts of grey box and display box data types. These make explicit the idea that state variables in abstract data types are not always hidden.
Boiten, Eerke Albert, Derrick, John
core +1 more source
Black-box Hamiltonian simulation and unitary implementation
, 2011 We present general methods for simulating black-box Hamiltonians using quantum walks. These techniques have two main applications: simulating sparse Hamiltonians and implementing black-box unitary operations.
Berry, Dominic W., Childs, Andrew M.
core +1 more source
Cancer Discovery, 2017 Abstract Summary: A better understanding of the mechanisms by which tumor rejection succeeds and fails is needed to improve immunotherapies. Here, Anagnostou and colleagues find that mutations predicted to be the most immunogenic are preferentially lost when cancer progresses through checkpoint blockade. Cancer Discov; 7(3); 250–1. ©2017
openaire +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source