Results 81 to 90 of about 45,642 (282)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Racialised Italians’ response to #BLM: Forms of solidarity, activism and community building on digital spaces [PDF]
Feminist Encounters: A Journal of Critical Studies in Culture and PoliticsFollowing the rise of the #MeToo movement, the social isolation that followed the Covid-19 pandemic and the global ascent of the Black Lives Matter movement, there has been an increase in discussions and initiatives on digital platforms.
Nathasha Edirippulige Fernando
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Black Lives Matter… but to Whom? An Examination of Nationally-Grounded Determinants of Black Lives Matter Support. [PDF]
Int Rev Soc Psychol, 2023 Lankester LA, Alexopoulos T.
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Role of Social Media in Social Movements: The Case of Black Lives Matter
, 2016 The motivation for this thesis is to explore the social movement of Black Lives Matter to discover and analyze the reasons for its formation, associated events that have taken place, and most of all the societal impact the movement has had on America and
Hamilton, Jordan
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
What Black Lives Matter can learn from the 1960s struggle for Civil Rights
, 2018 For the past five years, the Black Lives Matter movement has attempted to tackle the systemic racism present in the US which dehumanizes and devalues the lives of its black citizens. Dewey M.
Clayton, Dewey M.
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
, 2021 Parker, Karen F.Until recently research on Black civil resistance in America has remained heavily concentrated on the Civil Rights Movement. However, the rise of the Black Lives Matter (BLM) movement has created an opportunity to advance this field of ...
Anderson, Chanya
core +1 more source