Results 41 to 50 of about 13,101,410 (290)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Y. N. HARARI, FROM SAPIENS TO DEUS
Y. N. Harari, From Sapiens to Deus. This article considers the two most recent books by Y. N. Harari, Sapiens (2011) and Homo Deus (2015) and tries to critically discuss the main themes: the cognitive, agricultural, scientific (including industrial ...
Jacques COULARDEAU
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Unruh thermal hadronization and the cosmological constant
We use black holes with a negative cosmological constant to investigate aspects of the freeze-out temperature for hadron production in high energy heavy-ion collisions.
Antonia M. Frassino +2 more
doaj +1 more source
Terry M. Black to the Jacksons
Terry M. Black, writing from Camp Pendleton, California, to his parents, the Jacksons, in Van Buren, Arkansas, discusses his feelings about his recent leave in Van Buren, the current plans for his unit's deployment, and some of the training and duty he ...
Black, Terry Moore, 1946-2022;
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
1962 Annual Review, Black Hills National Forest
Annual report for the Black Hills National Forest. "GPO 831935.
Black Hills National Forest (Agency : U.S.)
core
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Aussteigen (getting out) Impossible—Montage and Life Scenarios in Andres Veiel’s Film Black Box BRD
Andres Veiel’s 2001 documentary film, Black Box BRD, links the biography of Alfred Herrhausen, RAF victim, with one of the 3rdgeneration RAF terrorists, Wolfgang Grams. In my paper, I trace how the film’s aesthetics introduce an image montage of two life
Anja Katharina Seiler
doaj +1 more source

