Results 51 to 60 of about 6,064,014 (277)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Non Uniform Black Strings and Critical Dimensions in $AdS_d$
, 2009 We study the equations of black strings in spacetimes of arbitrary dimensions with a negative cosmological constant and construct numerically non uniform black strings solutions.
D. Klemm +13 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Counting microstates of out-of-equilibrium black hole fluctuations
Journal of High Energy PhysicsWe construct and count the microstates of out-of-equilibrium eternal AdS black holes in which a shell carrying an order one fraction of the black hole mass is emitted from the past horizon and re-absorbed at the future horizon.
Vijay Balasubramanian +4 more
doaj +1 more source
Y. N. HARARI, FROM SAPIENS TO DEUS
Studia Universitatis Babeş-Bolyai. Philologia, 2018 Y. N. Harari, From Sapiens to Deus. This article considers the two most recent books by Y. N. Harari, Sapiens (2011) and Homo Deus (2015) and tries to critically discuss the main themes: the cognitive, agricultural, scientific (including industrial ...
Jacques COULARDEAU
doaj +1 more source
Black-out: publieke electriciteitsproductie vereist [PDF]
, 2012 After construction flaws were detected in the steel reactor hull of possibly 22 nuclear power plants, corporate spokesmen blame the government for a possible black-out: investments have been postponed due to an unfavorable climate, low consumer tariffs ...
Roels, Frank
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Unruh thermal hadronization and the cosmological constant
Physics Letters B, 2018 We use black holes with a negative cosmological constant to investigate aspects of the freeze-out temperature for hadron production in high energy heavy-ion collisions.
Antonia M. Frassino +2 more
doaj +1 more source