Results 51 to 60 of about 3,603 (219)

مقاصد الشريعة وأثرها في حماية المجتمع وصيانة أفراده (الابتزاز الالكتروني) أنموذجاً دراسة أصولية مقاصدية / The objectives of Sharia law and its impact on protecting society and preserving its members (electronic blackmail) as a model, a fundamentalist study of objectives [PDF]

مجلة البحوث الفقهیة والقانونیة
يهدف هذا البحث إلى دراسة مقاصد الشريعة وأثرها في حماية المجتمع وصيانة أفراده         ( الابتزاز الإلكتروني ) أنموذجاً. وجريمة الابتزاز الإلكتروني تعتبر من الجرائم المستحدثة التي ظهرت في المجتمع مع التطور التقني والتكنولوجي الحديث والتي ترتب عليها نقض ...
محمود محمد أحمد السيد سالم
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

المواجهة الجنائية والأمنية لجرائم الابتزاز الإلكتروني (دِرَاسة مُقارنة) / Criminal And Security Confrontation Of Cyber-Extortion Crimes (Comparative Study) [PDF]

مجلة البحوث الفقهیة والقانونیة
أدى التطور العلمي الحديث في مجال التحول الرقمي إلى تخزين غالبية أسرار الأفراد على الشبكات الإلكترونية، مما جعل من السهل الوصول إلى تلك المعلومات والأسرار من خلال اختراق الأنظمة الإلكترونية التي تحتفظ بها, وقد أسهم انتشار الإنترنت وتقنياته في ظهور أنماط ...
اسلام ندا
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Lightweight and hybrid transformer-based solution for quick and reliable deepfake detection

Frontiers in Big Data
IntroductionRapid advancements in artificial intelligence and generative artificial intelligence have enabled the creation of fake images and videos that appear highly realistic.
Geeta Rani, Atharv Kothekar, Shawn George Philip, Vijaypal Singh Dhaka, Ester Zumpano, Ester Zumpano, Eugenio Vocaturo, Eugenio Vocaturo   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

الإكراه المعنوي وأثره في التصرفات (الابتزاز الإلكتروني أنموذجًا) / Moral Coercion And Its Impact On Behavior (Electronic Blackmail) [PDF]

مجلة البحوث الفقهیة والقانونیة
يستعرض البحث موضوع الإكراه المعنوي وأثره في التصرفات، وذلك بتنزيله على الابتزاز الإلكتروني، أحد أشكال الإكراه  المعنوي في العصر الحاضر؛ هذا النوع من الابتزاز أحد سلبيات التكنولوجيا الحديثة، والذي يُعتبر ظاهرة جديدة نتجت عن التطور التكنولوجي السريع، حيث ...
هالة علي محمد عبد المنعم سلامة
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

MODERNIZAREA DEFINIŢIEI LEGALE A CONCEPTULUI DE ŞANTAJ

Studia Universitatis Moldaviae: Stiinte Sociale, 2007
The article discusses the question of modernizing the legal definition of the concept of blackmail. The author puts into discussion the controversies and the solutions regarding the quality improving of the legislative definition of the notion ...
USM ADMIN
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source