Results 101 to 110 of about 1,392,998 (338)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
In Search of a Singular I: A Structurational Analysis of Passing [PDF]
, 2005 It is easy to envision the socio-cultural phenomenon of passing as a relic of a bygone era, yet passing is markedly more. From a historical perspective, passing-as-white is a strategy of representation through which light-skinned, white-looking ...
Alesan, Dawkins Marcia
core +1 more source
Letting the System Completely Absorb Me Would Be So Much Easier [PDF]
, 2020 SchwarzRund is a Black Dominican queer femme feminist, active in intersectional education, Black German publishing and spoken word, empowerment around Fatness, Blackness, Queerness, and allyship, and critical media research.
Gramling, David, Ploschnitzki, Patrick
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Third World Themes in the International Politics of the Ceaușescu Regime or the International Affirmation of the ‘Socialist Nation’ [PDF]
, 2018 The present article aims to offer a synoptic picture of communist Romania’s relations with Third World countries during the Ceaușescu regime. Within these relations, economic and geopolitical motivations coexisted along with ideological ones, thus making
Copilaș, Emanuel
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
, 2015 Linguists have long been aware that the language scripted for ethnic roles in the media has been manipulated for a variety of purposes ranging from the construction of character authenticity to flagrant ridicule.
Bloomquist, Jennifer
core
Strategic Afro-Modernism, Dynamic Hybridity, and Bebop's Socio-Political Significance [PDF]
, 2013 In this chapter, I argue that one can articulate a historically attuned and analytically rich model for understanding jazz in its various inflections. That is, on the one hand, such a model permits us to affirm jazz as a historically conditioned, dynamic
Nielsen, Cynthia R.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Nuclear Physics B, 1986 Abstract We give a new derivation for the properties of radiation appearing to an observer bounded in a space-time domain that has a horizon; this includes the Rindler case (constant accelerating frame) and the Schwarzschild solution (black hole). Because of the global nature of the quantum state, which inevitably extends to space beyond the horizon,
openaire +1 more source