Results 71 to 80 of about 331,825 (303)

A novel oncogenic protein in the Progranulin\EphA2 axis: the role of Myoferlin in bladder cancer

, 2022
reservedThe growth factor progranulin plays a key role in bladder cancer by promoting cell motility and invasion. Until recently, the progranulin signaling receptor remained unknown precluding a full comprehension of progranulin action in cancer.
RUGGIERO, VALENTINA
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Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Molecular profiling of bladder cancer xenografts defines relevant molecular subtypes and provides a resource for biomarker discovery.

Translational Oncology
Bladder cancer (BLCA) genomic profiling has identified molecular subtypes with distinct clinical characteristics and variable sensitivities to frontline therapy. BLCAs can be categorized into luminal or basal subtypes based on their gene expression.
Sharada Mokkapati, Ganiraju Manyam, Alexis R. Steinmetz, Côme Tholomier, Alberto Martini, Woonyoung Choi, Bogdon Czerniak, Byron H Lee, Colin P Dinney, David J McConkey   +9 more
doaj   +1 more source

The influence of glutathione S-transferases M1 and M3 on the development of bladder cancer [PDF]

Problem: Cigarette smoking is the most important risk factor of transitional cell carcinoma of the urinary bladder. The effect of the glutathione S- transferases M1 (GSTM1) and M3 (GSTM3) on the influence of this risk factor was investigated.
Golka, Klaus, Bolt, Hermann M., Selinski, Silvia, Schmidt, Tobias   +3 more
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Low Frequency of Intratumor Heterogeneity in Bladder Cancer Tissue Microarrays [Elektronisk resurs]

, 2018
Background: Intratumoral heterogeneity (ITH) is associated with clinical challenges such as possible differences in response to treatment and difficulties in classifying the tumor.
Liedberg, Fredrik,, Sjödahl, Gottfrid,, Jakobsson, Lovisa,, Chebil, Gunilla,, Lund University., Marzouka, Nour Al Dain,   +5 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Metastatic non-muscle invasive bladder cancer with cervical lymph node metastasis. [PDF]

, 2019
Bladder cancer is a common cancer that may present as superfi cial, invasive, or metastatic disease. Non‐muscle‐invasive bladder cancer (NMIBC) represents the majority of bladder cancer diagnoses, but represents a spectrum of disease with a variable ...
García Martín, Luis, Villar Zarra, Karen, Garrido-Abad, Pablo, Díaz Menéndez, Ariel, Fernández Arjona, Manuel   +4 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Impact of the Level of Urothelial Carcinoma Involvement of the Prostate on Survival after Radical Cystectomy

Bladder Cancer, 2017
Objective: Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports.
Marco Moschini, Francesco Soria, Martin Susani, Stephan Korn, Alberto Briganti, Morgan Roupret, Christian Seitz, Killian Gust, Andrea Haitel, Francesco Montorsi, Gregory Wirth, Brian D. Robinson, Pierre I. Karakiewicz, Mehmet Özsoy, Michael Rink, Shahrokh F. Shariat   +15 more
doaj   +1 more source

Microarray analysis of pathways involved in bladder cancer invasion and metastasis.

, 2008
MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
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