Results 61 to 70 of about 433,450 (245)

Urinary diversion and bladder reconstruction/replacement using intestinal segments for intractable incontinence or following cystectomy [PDF]

, 2012
Background Surgery performed to improve or replace the function of the diseased urinary bladder has been carried out for over a century. Main reasons for improving or replacing the function of the urinary bladder are bladder cancer, neurogenic bladder ...
Neal, David E., Yong, Sze M., Cody, June D., Pickard, Robert, Nabi, Ghulam, McClinton, Samuel, Dublin, Norman   +6 more
core   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Cistectomia radical laparoscópica com reservatório ileal

Revista do Colégio Brasileiro de Cirurgiões
Worldwide experience with laparoscopic radical cystectomy is increasing in the last few years. We describe a 29-year-old female who underwent a laparoscopic radical cystectomy with ileal reservoir for a bladder sarcoma. Operative time was 405 minutes and
Anibal Wood Branco, William Kondo, Alcides José Branco Filho, Luciano Carneiro Stunitz, Marco Aurélio de George   +4 more
doaj   +1 more source

Urinary bladder radiotherapy-related chondroblastic osteosarcoma: Rare case report and review of literature

Urology Annals, 2014
Radiation-related osteosarcomas are well described malignant mesenchymal neoplasms, yet their pathogenesis is not fully understood. They are generally classified into either skeletal osteosarcomas, or their and rare soft tissue counterpart.
Noorah Almadani, Khaled O. Alsaad, Hamoud Al-Matrafi, Abdulrahman Al Hadab, Nouf Abdullah, Abdulmohsen AlKushi   +5 more
doaj   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane

, 2007
Multidrug resistance (MDR) describes the phenomenon whereby cancer cellsexposed to a single cytotoxic drug develop cross resistance to numerous otherstructurally unrelated chemotherapeutics.
Featherstone, Jonathan Mark
core   +1 more source

Multiple primary malignancies

Bangabandhu Sheikh Mujib Medical University Journal, 2017
Two cases of multiple primary malignancies (two or more neoplasms without any relationship between them) are presented in this paper. The first case (65 years) was a male in whom follicular carcinoma of thyroid, metachronous neuroendocrine tumor of ...
Dibanur Rashid Siddiqua, Shamim Ahmed, Rajashish Chakrabortty, Mohammed Atiqur Rahman   +3 more
doaj   +1 more source

Empirical distributions (o) of ED₀₁ study data on bladder neoplasms, liver neoplasms, and bladder carcinomas resulting from continuous exposure to the carcinogen 2-acetylaminofluoren, and fitted Weibull (—) and first-order time-transform (−) distributions.

, 2015
Columns 1–3: liver neoplasms, bladder neoplasms, and bladder carcinomas, respectively; Rows 1–3: 75, 100, and 150 ppm, respectively. Bladder neoplasm and bladder carcinoma data are identical at 75 and 100 ppm (all neoplasms malignant), therefore not ...
James D. Englehardt (752917)
core   +1 more source