Results 81 to 90 of about 433,450 (245)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Global, regional, and National burden of urologic neoplasms from 1990 to 2021 and future projections to 2050, a comprehensive analysis for global burden of disease

Discover Oncology
Background Urologic neoplasms are considered to pose a serious threat to patients’ lives and quality of life. Analyzing and describing the global disease burden of urologic neoplasms is necessary.
Zhao Yang, Yu Xinyang, Xu Xiaoqing, Qi Yuanfu, Dai Xin   +4 more
doaj   +1 more source

Urovysion™ testing can lead to early identification of intravesical therapy failure in patients with high risk non-muscle invasive bladder cancer

International Brazilian Journal of Urology, 2009
Purpose: In this study, we investigated the ability of UroVysion™ to assess response to intravesical therapy in patients with high risk superficial bladder tumors.
Jared M. Whitson, Anna B. Berry, Peter R. Carroll, Badrinath R. Konety   +3 more
doaj   +1 more source

Editorial comment on: increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells [PDF]

, 2007
No abstract ...
Leung, H.Y., Edwards, J.
core   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study. [PDF]

Front Genet, 2022
Du W, Wang T, Zhang W, Xiao Y, Wang X.
europepmc   +1 more source

Cyclooxygenase-2 Expression in Bladder Cancer and Patient Prognosis: Results from a Large Clinical Cohort and Meta-Analysis [PDF]

, 2012
27/02/14 meb.
Manuel M. Morente (135761), Real, FX, Real, Francisco X., Morente, Manuel M., Kogevinas, Manolis, Adonina Tardón, SBC/EPICURO investigators, Real Francisco X., Montes-Moreno, S, Montes-Moreno Santiago, Carrato, Alfredo, Amaral André F. S., Maciej J Czachorowski, André F. S. Amaral (135752), Maciej J. Czachorowski (135750), Santiago Montes-Moreno, Czachorowski, Maciej J., Malats Núria, Morente, MM, Santiago Montes-Moreno (135753), Kogevinas, M, André F S Amaral, Manolis Kogevinas, Amaral, André F.S., Amaral, André F. S., Tardón Adonina, Czachorowski, Maciej J, Morente, Manuel M, Josep Lloreta, Manolis Kogevinas (135763), Francisco X Real, Carrato Alfredo, Alfredo Carrato (135757), Tardón, Adonina, Malats, N, Morente Manuel M., Montes Moreno, Santiago, Tardón García, Adonina, Czachorowski Maciej J., Núria Malats (135767), Malats i Riera, Núria, Kogevinas Manolis, Alfredo Carrato, Carrato, A, Francisco X. Real (135765), Adonina Tardón (135759), Montes-Moreno, Santiago, Lloreta, Josep, Josep Lloreta (135755), Malats Riera, Núria, Carrato Mena, Alfredo, Núria Malats, Lloreta Josep, Manuel M Morente, Tardón, A, Lloreta, J, Czachorowski, MJ, Amaral, AFS, Lloreta, Josep, 1958-   +58 more
core   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Anaplastic lymphoma kinase1 positive inflammatory myofibroblastic tumor of the urinary bladder: A rare mesenchymal neoplasm with diagnostic and therapeutic implications

SAGE Open Medical Case Reports
Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms characterized by spindle-cell morphology with accompanying inflammatory infiltrates.
FNU Poombal, Ibrahim Mansoor, Randa M Abdellatif, Nada Shaker   +3 more
doaj   +1 more source

Serous Cystadenoma of the Pancreas Presenting as a Third Primary Neoplasm

Canadian Journal of Gastroenterology, 2003
Serous cystadenomas are the most common cystic neoplasms of the pancreas. They may occur solely or coexist with other neoplasms. A 10 cm mass involving the body of the pancreas was observed in the computed tomography of a 61-year-old man with a previous ...
Aydın Şeref Köksal, Aysel Ülker, Mehmet Asıl, Bilge Tunç, Arda Kemal, Metin Şavkılıoğlu, Yusuf Özoğul, Nesrin Turhan   +7 more
doaj   +1 more source