Results 91 to 100 of about 68,161 (247)

Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers‐Danlos Syndrome

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction and Objectives Hypermobile Ehlers‐Danlos Syndrome (hEDS) is the most common subtype of Ehlers‐Danlos Syndrome, a group of connective tissue disorders caused by collagen abnormalities. While musculoskeletal features of hEDS are well characterized, its impact on visceral organs, including the bladder, remains underexplored.
Marium Ansari, Mallory Pine, Viktoriya Sapkalova, Emily Chan Brodowsky, Charles R. Powell, Ramzy T. Burns   +5 more
wiley   +1 more source

Pathology and physiology of acid-sensitive ion channels in the bladder

Heliyon
Acid-sensitive ion channels (ASICs) are sodium-permeable channels activated by extracellular acidification. They can be activated and trigger the inward flow of Na+ when the extracellular environment is acidic, leading to membrane depolarization and thus
Yang Zhang, Di Dong, Jialong Zhang, Kang Cheng, Fang Zhen, Mei Li, Binghai Chen   +6 more
doaj   +1 more source

Lived Experiences of Emotional Distress Among Patients With Lower Urinary Tract Symptoms: A Mixed‐Methods Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose We aimed to describe the association of lower urinary tract symptoms (LUTS) with emotional distress using questionnaires and qualitative interviews. Methods We used a convergent parallel mixed methods design to examine relationships between the LURN Symptom Index‐29 (LURN SI‐29) questionnaire and emotional distress, measured by the ...
Grace E. Bardwick, Alan J. Fossa, Hosanna An, Jessica Thomas, Brian Bieber, Kathryn E. Flynn, Giulia M. Ippolito, Melissa Marquez, Michelle Taddeo, James W. Griffith, the LURN Study Group, Cindy Amundsen, J. Eric Jelovsek, Kathryn Flynn, Jim Hokanson, Aaron Lentz, David Page, Nazema Siddiqui, Todd Harshbarger, Michael Odom, Chad Gridley, Jordan Foreman, Tara Morgan, Annika Sinha, Aya Bashi, Jasmine Arrington, Magaly Guerrero, Stephanie Yu, Catherine S. Bradley, Karl Kreder, Bradley A. Erickson, Daniel Fick, Vince Magnotta, Philip Polgreen, Nancy Hollenbeck, C. Emi Bretschneider, James W. Griffith, Kimberly Kenton, Brian Helfand, David Cella, Julia Geynisman‐Tan, Alex Glaser, Margaret Mueller, Francesca Farina, Richard Fantus, Devin Boehm, Melissa Marquez, Malgorzata Antoniak, Pooja Talaty, Karen John, Jinxuan Shi, Tara Samsel, Brian Helfand, Alex Glaser, Malgorzata Antoniak, Pooja Talaty, C. Emi Bretschneider, David Cella, Julia Geynisman‐Tan, Devin Boehm, Melissa Marquez, Karen John, J. Quentin Clemens, John DeLancey, Dee Fenner, Rick Harris, Steve Harte, Anne P. Cameron, Aruna Sarma, Giulia M. Ippolito, Priyanka Gupta, Whitney Horner, Jannah Thompson, Payton Schmidt, Greg Mowatt, Sarah Richardson, Sneha Mathai, Syedah Mubeenah, Claire Yang, Anna Kirby, Swati Rane Levendovszky, Sreya Gutta, Brenda Vicars, Holly Covert, H. Henry Lai, Joshua Shimony, Fuhai Li, Patricia Hayden, Aleksandra Klim, John Graff, Victor Andreev, Brenda Gillespie, Jessica Durkin, Melissa Sexton, Julia Nashif, Brian Bieber, Nathan Goodrich, Calvin Andrews, Jon Wiseman, Naveen Fawaz, Bethesda Maryland, Ziya Kirkali, Christopher Mullins   +102 more
wiley   +1 more source

Fear‐Avoidance and Overactive Bladder: Toward a Mechanism‐Informed Model of Care

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Overactive bladder (OAB) is associated with substantial psychological burden, yet existing biopsychosocial frameworks acknowledge that psychological factors shape outcomes without explaining the cognitive and behavioral mechanisms through which that influence operates.
Rupal M. Patel, Andrea Wood
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Core stability in women with and without chronic pelvic pain

PM&R, EarlyView.
Abstract Background Physical activity (PA) and core stability levels are unknown for women with musculoskeletal chronic pelvic pain (CPP) compared to healthy women. At this time, there is no validated treatment method aimed specifically at CPP. Objective To elucidate the PA habits and core stability of women with and without CPP.
Hannah V. Chatwin, Abhilasha Kumar, Michael Wesolowski, Laura Glaser, Colleen M. Fitzgerald, Stacey Bennis   +5 more
wiley   +1 more source

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Vaginal Oestrogen Therapy for Postmenopausal Women Undergoing Prolapse Surgery: A Multicentre Double‐Blind Randomised Placebo‐Controlled Clinical Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine whether vaginal oestrogen therapy improves outcomes after prolapse surgery in postmenopausal women. Design Double‐blind, randomised, placebo‐controlled trial with 12 month follow‐up. Setting Multicentre, 22 hospitals in the Netherlands.
Eva V. Vodegel, Krista van Rest, Leonie Speksnijder, Astrid Vollebregt, Albert Adriaanse, Eveline J. Roos, Franca Gerards, Wilbert Spaans, Marko Sikkema, Joggem Veen, Flora Vernooij, Marinus van der Ploeg, Jan‐Paul W. R. Roovers, the EVA Study Group, Alfredo L. Milani, Mirjam Weemhoff, Anne Damoiseaux, Heleen van Dongen, Marieke Mous, Pieternel Steures, Geerte van de Pol, Bart Broekman, Fernando Tjin Asjoe, Jolande van der Stege, Ronald Mouw, Ruben G. Duijnhoven   +25 more
wiley   +1 more source