Results 51 to 60 of about 143,268 (301)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Investigation of the direct and indirect mechanisms of primary blast insult to the brain

Scientific Reports, 2021
The interaction of explosion-induced blast waves with the head (i.e., a direct mechanism) or with the torso (i.e., an indirect mechanism) presumably causes traumatic brain injury.
Jose E. Rubio, Ginu Unnikrishnan, Venkata Siva Sai Sujith Sajja, Stephen Van Albert, Franco Rossetti, Maciej Skotak, Eren Alay, Aravind Sundaramurthy, Dhananjay Radhakrishnan Subramaniam, Joseph B. Long, Namas Chandra, Jaques Reifman   +11 more
doaj   +1 more source

An animal-to-human scaling law for blast-induced traumatic brain injury risk assessment [PDF]

, 2014
Despite recent efforts to understand blast effects on the human brain, there are still no widely accepted injury criteria for humans. Recent animal studies have resulted in important advances in the understanding of brain injury due to intense dynamic ...
Jean, Aurelie H., Joannopoulos, John D., Joannopoulos, John D., Moore, David Francis, Nyein, Michelle K., Radovitzky, Raul, Zheng, James Q.   +6 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Blast-Associated Shock Waves Result in Increased Brain Vascular Leakage and Elevated ROS Levels in a Rat Model of Traumatic Brain Injury. [PDF]

PLoS ONE, 2015
Blast-associated shock wave-induced traumatic brain injury (bTBI) remains a persistent risk for armed forces worldwide, yet its detailed pathophysiology remains to be fully investigated.
Shushi Kabu, Hayder Jaffer, Marianne Petro, Dave Dudzinski, Desiree Stewart, Amy Courtney, Michael Courtney, Vinod Labhasetwar   +7 more
doaj   +1 more source

Bomb blast injuries: an exploration of patient characteristics and outcome using Pakistan National Emergency Departments Surveillance (Pak-NEDS) data. [PDF]

, 2015
BACKGROUND: Bomb blast injuries result in premature deaths and burdening of healthcare systems. The objective of this study was to explore the characteristics and outcome of patients presenting to the emergency departments in Pakistan with bomb blast ...
Afridi, Shiraz Qayoom, Allen, Kate, Hyder, Adnan A., Kerai, Salima, Khan, Irum Qamar, Khan, Nadeem Ullah, Khan, Uzma Rahim, Naeem, Rubaba, Razzak, Junaid Abdul, Shahbaz, Sana, Siddiqui, Emaduddin, Zia, Nukhba   +11 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Modeling biomarker kinetics of Aβ levels in serum following blast

Frontiers in Neurology
Elucidating the unique neuropathological response to blast exposure remains a barrier towards the development of diagnostic approaches for those with blast-induced traumatic brain injury (bTBI).
Carly Norris, Harsha T. Garimella, Walter Carr, Angela M. Boutté, Raj K. Gupta, Andrzej J. Przekwas   +5 more
doaj   +1 more source

Spectrum of abdominal organ injury in a primary blast type

World Journal of Emergency Surgery, 2009
Introduction Abdominal organ injury in a primary blast type is always challenging for diagnosis. Air containing abdominal viscera is most vulnerable to effects of primary blast injury.
Amin Abid, Wani Rauf A, Sheikh Tariq, Parray Fazal Q, Wani Imtiaz, Gul Imran, Nazir Mir   +6 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source