Results 71 to 80 of about 51,064 (306)
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
Molecular Brain, 2018 Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various severity levels. Primary TBI from blast exposure is commonly characterized by internal injuries, such as vascular damage, neuronal injury, and contusion ...
Adan Hernandez +11 more
doaj +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Mathematical models of blast induced TBI: current status, challenges and prospects
Frontiers in Neurology, 2013 Blast induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the
Raj K Gupta, Andrzej ePrzekwas
doaj +1 more source
Neuronal Injury and Glial Changes Are Hallmarks of Open Field Blast Exposure in Swine Frontal Lobe. [PDF]
PLoS ONE, 2017 With the rapid increase in the number of blast induced traumatic brain injuries and associated neuropsychological consequences in veterans returning from the operations in Iraq and Afghanistan, the need to better understand the neuropathological sequelae
Srinivasu Kallakuri +8 more
doaj +1 more source
, 2002 A case of blast injury with tympanic perforation and limb laceration is reported. The classification (into four types), mechanism and pathogenesis of blast injury are discussed.
Ky Cheung, Sh Leung, Cw Kam, Hh Yau
core +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
, 2011 Blast injuries are an increasing problem in both military and civilian practice. Primary blast injury to the lungs (blast lung) is found in a clinically significant proportion of casualties from explosions even in an open environment, and in a high ...
S. Watts, E. Kirkman, G. Cooper
core +1 more source
Advanced Science, EarlyView.This work proposed a pollen‐enhanced bionic mechanoreceptor based on ionic convection. Leveraging the ion anchoring effect of the pollen particle, the output performance could be ∼12 times higher than the original state. By employing deep learning models as AI brains, the feasibility of a sensory‐augmented prosthesis consisting of a pollen‐enhanced ...
Zi Hao Guo +7 more
wiley +1 more source
Advanced Science, EarlyView.Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi +7 more
wiley +1 more source