Results 51 to 60 of about 1,330,518 (288)

Study on blast load distribution of building surface under surface burst

Baozha yu Chongji
In order to study the distribution of blast wave load of building surface under surface burst, firstly, the fine scaled experiments under laboratory environment were conducted.
Long MA, Wenjun YIN, Qi LI, Junyi GUAN, Nianxue TONG, Shuai CHENG, Wenxiang LIU, Dezhi ZHANG   +7 more
doaj   +1 more source

Blast Loading and Blast Effects on Structures – An Overview

Electronic Journal of Structural Engineering, 2007
The use of vehicle bombs to attack city centers has been a feature of campaigns by terrorist organizations around the world. A bomb explosion within or immediately nearby a building can cause catastrophic damage on the building's external and internal structural frames, collapsing of walls, blowing out of large expanses of windows, and shutting down of
Tuan Ngo, Priyan Mendis, A. Gupta, J. Ramsay   +3 more
openaire   +2 more sources

A new non-uniform blast load model for SDOF method of one-way reinforced concrete slab

EPJ Web of Conferences, 2012
A new effective model for calculation of the equivalent uniform blast load for non-uniform blast load such as close-in explosion of a one-way square and rectangle reinforced concrete slab is proposed in this paper.
Wang S.-C., Lu F., Zhang D., Wang W., Tang F.   +4 more
doaj   +1 more source

Shock-absorbing design of a seat of a military vehicle subject to blast load (Proposal of hook-spring mechanism)

Nihon Kikai Gakkai ronbunshu, 2016
Armored fighting vehicles with Mine Resistant Ambush Protected (MRAP) designed to counter Improvised Explosive Devices (IEDs) have recently attracted special interest.
Hiroyuki FUJIWARA, Osamu TOKUDA, Keiji WATANABE   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Cunningham: a BLAST Runtime Estimator [PDF]

, 2011
BLAST is arguably the single most important piece of software ever written for the biological sciences. It is the core of most bioinformatics workflows, being a critical component of genome homology searches and annotation.
Malcolm Matalka, James R. White, James White, Samuel V. Angiuoli, W. Florian Fricke, Samuel Angiuoli   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Safe dynamic design of structures. [PDF]

, 2000
The Design of structures under dynamic loading is a demanding subject in safety of engineering design since conventional static failure criteria are unable to deal with structures under transient loading.
Moatamedi, Mojtaba
core   +5 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source