Results 61 to 70 of about 1,330,518 (288)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Measurement of Damping Ratios of Hollow Sandwich Slabs Under Close-Contact Blast Load

Buildings
To prevent structural damage in a contact explosion, the blast load must be discharged without damaging the structure. Contact blast tests were conducted in our study using TNT-equivalent explosives of between 125 g and 350 g, and prefabricated hollow ...
Dursun Bakır, Sedat Savaş
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigation on the Dynamic Response and Failure Mode of Clay Brick Masonry Walls Under Long-Duration Explosion

Buildings
Masonry structures are widely used in civil engineering due to their favorable load-bearing capacity and construction efficiency; however, the threat posed by long-duration blast loads from industrial accidents and large-yield explosions has become ...
Chengrui Wang, Kai Zhang, Wei Liu, Peng Li, Ming Yang, Xiaolei Chen   +5 more
doaj   +1 more source

Blast responses of shallow-buried prefabricated modular concrete tunnels reinforced by BFRP-steel bars

Underground Space, 2022
This paper reports the anti-blast performance of shallow-buried prefabricated modular tunnel reinforced by basalt fiber-reinforced polymer (BFRP) -steel bars.
Chengjie Zhao, Zexun Tang, Peng Wang, Jiang Feng, Jiannan Zhou, Xinli Kong, Hansheng Geng, Fengnian Jin, Hualin Fan   +8 more
doaj   +1 more source

A Thoracic Mechanism of Mild Traumatic Brain Injury Due to Blast Pressure Waves [PDF]

, 2008
The mechanisms by which blast pressure waves cause mild to moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the blast wave to
Michael Courtney, Amy Courtney
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Blast resistance of stiffened sandwich panels with closed-cell aluminum foam

Latin American Journal of Solids and Structures
In the present investigation, response of the stiffened sandwich foam panels with closed-cell aluminum foam cores subjected to blast load is examined. The panels have the metal foam sandwiched between two steel sheets.
Manmohan Dass Goel, Vasant A. Matsagar, Anil K. Gupta   +2 more
doaj   +1 more source

Numerical Simulation on Dynamic Behavior of Slab–Column Connections Subjected to Blast Loads

Applied Sciences, 2021
Although many studies on the blast-resistant performance of structures have focused mainly on single members such as beams and columns, there is little research on the behavior of joints that are subjected to blast loads.
Kwang Mo Lim, Taek Hee Han, Joo Ha Lee
doaj   +1 more source