Results 61 to 70 of about 1,394,036 (230)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

DEVELOPMENT OF A 3D NUMERICAL MODEL FOR SIMULATING A BLAST WAVE PROPAGATION SYSTEM CONSIDERING THE POSITION OF THE BLASTING HOLE AND IN-SITU DISCONTINUITIES

Rudarsko-geološko-naftni Zbornik, 2022
Blasting operations are one of the most important parts of geotechnical and mining projects. Most rocks naturally have a series of discontinuities that significantly affect their responses to blast waves. In this paper, the propagation of a blast wave in
Mojtaba Yari, Daniyal Ghadyani, Saeed Jamali   +2 more
doaj  

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

Advanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li, Gengyu Han, Boqing Jia, Jijian Lu, Changxu Zhang, Bin Wang, Jiaxiang Wang, Kang Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Min Li, Guoxi Luo, Tong Wang, Qijing Lin, Weishi Li, Libo Zhao, Yumeng Xue   +16 more
wiley   +1 more source

Advancements and future prospects in the fundamental theories of rock blasting research Ⅲ—Interaction mechanism between blast waves and cracks

工程科学学报
The “three relationships (the relationship between rock failure characteristics and blast loading, the superposition effect between blast waves and explosion gas, and the interaction between blast waves and cracks)” are important contents of the rock ...
Peng XU, Renshu YANG, Cheng CHEN, Chenxi DING, Yanbing WANG   +4 more
doaj   +1 more source

Tri‐Functional Electrocatalysis for Zinc–Air Battery Coupled Water Splitting: A Catalyst‐Electrode‐Device‐System Perspective

Advanced Science, EarlyView.
This review establishes a catalyst–electrode–device–system framework for tri‐functional HER/OER/ORR electrocatalysis that couples water splitting with Zn–air batteries. Five catalyst families are covered: noble‐metal, metal‐based, single‐atom, heterostructure, and metal‐free systems.
Xixi Di, Chao Duan, Shuzhen Li, Yiyang Che, Xiaoshuang Liu, Chuanyin Xiong, Mengxia Shen, Yichao Wang, Derek Hao, Yonghao Ni   +9 more
wiley   +1 more source

Mathematical models of blast induced TBI: current status, challenges and prospects

Frontiers in Neurology, 2013
Blast induced traumatic brain injury (TBI) has become a signature wound of recent military activities and is the leading cause of death and long-term disability among U.S. soldiers. The current limited understanding of brain injury mechanisms impedes the
Raj K Gupta, Andrzej ePrzekwas
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Blast-Induced Damage on Millisecond Blasting Model Test with Multicircle Vertical Blastholes

Shock and Vibration, 2015
To investigate the blast-induced damage effect on surrounding rock in vertical shaft excavation, 4 kinds of millisecond blasting model tests with three-circle blastholes were designed and carried out with excavation blasting in vertical shaft as the ...
Qin-yong Ma, Pu Yuan, Jing-shuang Zhang, Rui-qiu Ma, Bo Han   +4 more
doaj   +1 more source

Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to ‘composite’ blast.

Frontiers in Neurology, 2012
A number of experimental models of blast brain injury have been implemented in rodents and larger animals. However, the variety of blast sources and the complexity of blast wave biophysics have made data on injury mechanisms and biomarkers difficult to ...
Stanislav I. Svetlov, Stanislav I. Svetlov, Victor ePrima, Olena eGlushakova, Artem eSvetlov, Daniel eKirk, Hector eGutierrez, Victor eSerebruany, Kenneth eCurley, Kevin K W Wang, Ronald L Hayes   +10 more
doaj   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source