Results 51 to 60 of about 4,992,809 (126)

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Irradiation‐Induced CD62L Shedding in Human Plasmacytoid Dendritic Cells Depends on ADAM17 and p38 MAPK

Immunology, EarlyView.
Human plasmacytoid dendritic cell‐based vaccines efficiently migrate from blood to lymph nodes and prime naive T cells in humanised mice. Irradiation‐induced CD62L shedding, mediated by p38 MAP kinase and ADAM17, is involved in the regulation of PDC migration to secondary lymphoid organs in this model.
Estelle Leplus, Jamila Kacher, Dalil Hannani, Guillaume Vayssiere, Jean‐Paul Molens, Karine Laulanier, Dan Georgess, Véronique Josserand, Philippe Saas, Séverine Planel, Laurence Chaperot, Joel Plumas   +11 more
wiley   +1 more source

Salivary Methotrexate as a Predictor of Oral Mucositis in Hematological Cancer Patients: A Phase II Randomized, Double‐Blind Clinical Trial

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate the efficacy of prophylactic photobiomodulation therapy (PBMT) in preventing oral mucositis (OM) and to assess serum and salivary methotrexate (MTX) levels as predictors of OM in adults receiving high‐dose methotrexate (HD‐MTX).
Letícia Rodrigues‐Oliveira, Carolina Guimarães Bonfim, Ana Leticia Mores, Natalia Rangel Palmier, Henrique Ballassini Abdalla, Juliana Trindade Clemente‐Napimoga, Iara Gonçalves Aquino, Maria Cecilia Querido de Oliveira, Maria Cláudia Cuzzullin, Aljomar Jose Vechiato Filho, Cesar Rivera, Tatiana Natasha Toporcov, Juliana Pereira, Luiz Alcino Gueiros, Rossana Veronica Mendoza López, Manoela Domingues Martins, Marcelo Lazzaron Lamers, Karina Morais‐Faria, Pablo Agustin Vargas, Alan Roger Santos‐Silva, Thais Bianca Brandão, Ana Carolina Prado‐Ribeiro   +21 more
wiley   +1 more source

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Nature Communications, 2019
Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 ...
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida   +16 more
doaj   +1 more source

Liposomal Daunorubicin and Cytarabine, a Potential Therapy for Blastic Plasmacytoid Dendritic Cell Neoplasm

Journal of Investigative Medicine High Impact Case Reports, 2022
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive malignancy with poor outcomes. Although novel options like tagraxofusp, a CD123-directed cytotoxin, has emerged and is promising, treatment options are very limited in the relapsed
Prashanth Ashok Kumar MBBS, Mulham Ombada MBBS, Gayatri Pemmasani MBBS, Ajay Tambe MBBS, Katalin Banki MD, Teresa Gentile MD, PhD   +5 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Assessment of the Performance of Siemens Scopio Digital Morphology on Bone Marrow Aspirates in Onco‐Hematology

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 1000-1007, October 2026.
ABSTRACT Objectives Digital morphology (DM) systems assisted by artificial intelligence are increasingly being introduced into hematology laboratories; however, data on their performance in routine clinical practice for bone marrow aspirates (BMA) remain limited.
Gina Zini, John Marra, Elena Rossi, Silvia Bellesi, Nicoletta Pelliccioni, Giuseppe d'Onofrio, Patrizia Chiusolo   +6 more
wiley   +1 more source

Blastic Plasmacytoid Dendritic Cell Neoplasm–Current Insights

, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare clonal hematologic malignancy of plasmacytoid dendritic cell precursors. The presentation and clinical course of BPDCN is widely heterogeneous and was most recently categorized as a distinct ...
Venugopal, Sangeetha, Lane, Andrew A., Mascarenhas, John, Zhou, Selena, El Jamal, Siraj M.   +4 more
core   +1 more source

A novel mutation of IFT140 in a preschool child with Mainzer-Saldino syndrome accompanied by rare tumor blastic plasmacytoid dendritic cell neoplasm: a case report

BMC Pediatrics
Background Mainzer-Saldino syndrome is a rare autosomal recessive ciliopathy characterized by cone-shaped epiphyses, chronic renal failure, and early-onset severe retinal dystrophy.
Ruolan Hu, Jinrong Li, Fan Yang, Mingyan Jiang   +3 more
doaj   +1 more source

Flow cytometric identification of plasmacytoid dendritic cells in acute myeloid leukaemia: Challenges and practical considerations

British Journal of Haematology, EarlyView.
Mariana S. Vieira, Pietro B. Belmonte, Natália A. Marcondes, Raquel Q. Vidal, Flavo B. Fernandes, Liane N. Rotta   +5 more
wiley   +1 more source