Results 31 to 40 of about 36,742 (293)
Canadian Medical Association Journal, 2021 August 4, 2020, at 6:07 pm, I was sitting down, unwinding with my family, when the floor of our apartment began to shake. I knew the drill. As an emergency physician who had relocated to Beirut a decade ago, I had been through it countless times.
openaire +2 more sources
Effect of surface finishing such as sand-blasting and CrAlN hard coatings on the cutting edge’s peeling tools’ wear resistance [PDF]
, 2009 The authors would like to thank IonBond (Chassieu-France) who made the sand-blasting treatments and the Regional Council of Burgundy and CTBA (Wood and Furniture Technical Centre) for their financial support.The aim of this study is first to define the ...
NOUVEAU, Corinne +9 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Defence TechnologyAs a prototypical high-energy-density reactive material system, metastable intermolecular composites (MICs) have attracted considerable interest owing to their customizable component configurations and interfacial architectures.
Jingwei Li +14 more
doaj +1 more source
BLAST-QC: automated analysis of BLAST results [PDF]
Environmental Microbiome, 2020 AbstractBackgroundThe Basic Local Alignment Search Tool (BLAST) from NCBI is the preferred utility for sequence alignment and identification for bioinformatics and genomics research. Among researchers using NCBI’s BLAST software, it is well known that analyzing the results of a large BLAST search can be tedious and time-consuming. Furthermore, with the
Behzad Torkian +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Ain Shams Engineering JournalThe seismic retrofit of severely damaged composite joints is crucial for structural resilience and post-earthquake recovery. This study investigates the seismic performance of severely damaged recycled aggregate concrete-filled steel tubular (RACFST) T ...
Xiaoguang Zhou +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Energy Generation and Attenuation of Blast-Induced Seismic Waves under In Situ Stress Conditions
Applied Sciences, 2022 During blasting in deep mining and excavation, the rock masses usually suffer from high in situ stress. The initial seismic energy generated in deep rock blasting and its attenuation with distance is first theoretically analyzed in this study.
Jianhua Yang +3 more
doaj +1 more source