Results 41 to 50 of about 16,158 (263)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Numerical Integration Study of Penetration and Blasting Damage for Composite Underground Protective Structure with Reinforcement Layers

Buildings
In response to the increasing threat of powerful earth-penetrating weapons, underground protective structures typically employ composite structural systems with reinforced steel layers.
Xingji Zhu, Can Zhao, Longjun Xu, Yujin Wang, Shibin Lin, Guochen Zhao   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pioneering Insights into the Reaction Kinetics of Metastable Intermolecular Composites Based on Metal Fluorides: Virtually non‐existent condensed Phase Combustion Products and Ultra‐Efficient Reactivity

Advanced Science
As a typical representative of Metastable intermolecular composites (MICs), the energy release of nano‐thermites relying on aluminum‐oxygen reaction is limited by the formation of high boiling point condensed phase products.
Xuwen Liu, Jingwei Li, Shenghua Feng, Yongsheng Jia, Maocong Hu, Yingkang Yao, Jinshan Sun, Quanmin Xie, Hongqian Sang   +8 more
doaj   +1 more source

Response Characteristics and Safety Criterion of Double-Arch Tunnel Under Blast-Induced Disturbance from New Tunnel Excavation

Applied Sciences
Blast-induced vibrations from newly constructed tunnels may adversely affect adjacent existing tunnel structures. To ensure the safety of the existing tunnel, it is essential to investigate its dynamic response under blast disturbances.
Youxin Shao, Zhen Zhang, Jinshan Sun, Yingkang Yao, Nan Jiang, Shimao Ma   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Mechanical properties and energy dissipation law of saturated coal samples under dynamic loading

Meikuang Anquan
To investigate the mechanical properties and energy variation characteristics of saturated coal samples under dynamic loading, a 50 mm diameter split Hopkinson rod device (SHPB) was used to conduct impact loading tests on both saturated and natural coal ...
Tongzhao YAN, Ben NIU, Huang GUO, Baoliang ZHANG, Liwei CHEN   +4 more
doaj   +1 more source

BLAST: THE REDSHIFT SURVEY [PDF]

The Astrophysical Journal, 2009
Accepted for publication in the Astrophysical Journal. Maps and associated results are available at http://blastexperiment.info/
Eales, Stephen, Chapin, Edward L., Devlin, Mark J., Dye, Simon, Halpern, Mark, Hughes, David H., Marsden, Gaelen, MAUSKOPF, PHILIP, Moncelsi, Lorenzo, Netterfield, Calvin B., PASCALE, ENZO, Patanchon, Guillaume, Raymond, Gwenifer, Rex, Marie, Scott, Douglas, Semisch, Christopher, Siana, Brian, Truch, Matthew D. P., Viero, Marco P.   +18 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source