Results 41 to 50 of about 30,394 (314)

Study on the Charge Structure Optimization for Coal–Rock Mixed Blasting and Separate Mining in Open-Pit Mine with High Benches

Applied Sciences
This study systematically analyzes the influence of the charge length-to-diameter ratio and stemming length on the radius and volume of blasting craters in coal and rock blasting crater tests to effectively address the challenge of achieving coal–rock ...
Anjun Jiang, Honglu Fei, Yu Yan, Yanyu Liu, Shijie Bao, Jian Guo   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ultra-high pulse pressure induced particle surface thermal field assisted preparation of W–Al composite

Journal of Materials Research and Technology
Particle surface thermal field (PSTF) is an inhomogeneous thermal field that concentrates the heat effect on the surface of particles, and it can be utilized to fabricate composite materials with large differences in physical properties.
Jianian Hu, Haotian Zhang, Xiang Chen, Jian Zhang   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Blasting Vibration Generated by Breaking-Blasting Large Barriers with EBBLB [PDF]

, 2016
Equipment for breaking and blasting large barriers (EBBLB) is new break-blast equipment, which inevitably induces ground vibration and may cause substantial damage to rock mass and nearby structures as well as human beings.
Liu Jian-qing, Liu Xin, Xu Jing-lin, Liang Ting, Wang Zhen-xiong, Gu Wen-bin   +5 more
core   +1 more source

Design of bridge blasting demolition

, 2021
The paper presents the design of bridge blasting demolition scheme. The blasting methods has become the preferred method for bridge demolition not only in war period but also where bridge service life is exceeded.
Vladimir Kavicky, Michal Pilat, Stefan Jangl   +2 more
core   +1 more source

Numerical Integration Study of Penetration and Blasting Damage for Composite Underground Protective Structure with Reinforcement Layers

Buildings
In response to the increasing threat of powerful earth-penetrating weapons, underground protective structures typically employ composite structural systems with reinforced steel layers.
Xingji Zhu, Can Zhao, Longjun Xu, Yujin Wang, Shibin Lin, Guochen Zhao   +5 more
doaj   +1 more source

Predictive model of back-wall overpressure behind a cantilever wall

AIP Advances, 2023
To reduce the hazards posed by blast shock waves, important potential targets are usually shielded by cantilever walls. The main factor that indicates whether there is damage is the back-wall overpressure, and of concern here is predicting the back-wall ...
Quanmin Xie, Xinzhe Nian, Hui Zhou, Jianyuan Wu   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source