Results 41 to 50 of about 36,742 (293)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Simulation of the generation and propagation of blast induced shock waves [PDF]

, 2003
Hybrid modelling of blast vibration uses the signal produced from a single hole test shot to simulate the vibration that would be produced by a full-scale production blast.
Yuill, Gavin John
core   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Ultra-high pulse pressure induced particle surface thermal field assisted preparation of W–Al composite

Journal of Materials Research and Technology
Particle surface thermal field (PSTF) is an inhomogeneous thermal field that concentrates the heat effect on the surface of particles, and it can be utilized to fabricate composite materials with large differences in physical properties.
Jianian Hu, Haotian Zhang, Xiang Chen, Jian Zhang   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Observation and prediction of bottom collapse and middle break phenomena in the blasting demolition of high chimneys

Scientific Reports
In order to solve the key problems affecting the safety of the project, such as the collapse of the support part and break in the air of the reinforced concrete chimney during the blasting demolition, this paper carried out systematic monitoring and ...
Qiang Li, Jinshan Sun, Yongsheng Jia, Xiaowu Huang, Yingkang Yao, Yuqing Xia   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Study on the Charge Structure Optimization for Coal–Rock Mixed Blasting and Separate Mining in Open-Pit Mine with High Benches

Applied Sciences
This study systematically analyzes the influence of the charge length-to-diameter ratio and stemming length on the radius and volume of blasting craters in coal and rock blasting crater tests to effectively address the challenge of achieving coal–rock ...
Anjun Jiang, Honglu Fei, Yu Yan, Yanyu Liu, Shijie Bao, Jian Guo   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Source Model for Blasting Vibration

, 2002
By analyzing and comparing the experimental data, the point source moment theory and the cavity theory, it is concluded that the vibrating signals away from the blasting explosive come mainly from the natural vibrations of the geological structures near ...
Zheng ZM(郑哲敏), Ding H(丁桦)
core   +2 more sources