Results 101 to 110 of about 110,172 (282)
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
Understanding the ethical concerns that have shaped European regulation of human embryonic stem cell research [PDF]
, 2012 Human embryonic stem cell research has generated much hope, but also fear and repulsion. National legislators, as well as the European Parliament, the European Patent Office and the European Court of Justice have had to make decisions relating to what is
Mertes, Heidi
core
Clinical Genetics, EarlyView.This review primarily summarizes the genetic defects in Müllerian anomalies, the tools used to validate these genetic defects, and the future clinical significance of identifying the precise genetic etiology of Müllerian anomalies. ABSTRACT Müllerian anomalies are a collection of heterogeneous anatomical disorders of the female genital tract that ...
Jingfang Li +5 more
wiley +1 more source
Cell Proliferation, EarlyView.Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao +7 more
wiley +1 more source
The threshold of estradiol level for fresh embryo transfer differs between blastocyst and cleavage-stage embryo. [PDF]
Acta Obstet Gynecol ScandOur results suggested that the difference in pregnancy outcomes between fresh and frozen embryo transfer is related to the peak estradiol level and embryo transfer stage. The cutoff values for peak estradiol level for performing freeze‐all strategy to improve pregnancy outcomes were different for cleavage‐stage and blastocyst‐stage embryo transfer ...
Zhao D +12 more
europepmc +2 more sources
Cell Proliferation, EarlyView.Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen +5 more
wiley +1 more source
G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst
eLife, 2018 Early mouse development is regulated and accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2).
Jan J Zylicz +6 more
doaj +1 more source
Exposing dairy bulls to high temperature-humidity index during spermatogenesis compromises subsequent embryo development in vitro [PDF]
, 2020 Broekhuijse, Marleen L.W.J. +10 more
core +2 more sources
Vitrification of human immature oocytes before and after in vitro maturation: a review [PDF]
, 2017 The use of immature oocytes subjected to in vitro maturation (IVM) opens interesting perspectives for fertility preservation where ovarian reserves are damaged by pathologies or therapies, as in PCO/PCOS and cancer patients. Human oocyte cryopreservation
Ashourzadeh, S +5 more
core +1 more source