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The TGFβ pathway plays a pivotal role in early embryo lineage segregation [PDF]

open access: yes, 2012
Chuva de Sousa Lopes, Susana   +7 more
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The mammalian blastocyst

WIREs Developmental Biology, 2016
The blastocyst is a mammalian invention that carries the embryo from cleavage to gastrulation. For such a simple structure, it exhibits remarkable diversity in its mode of formation, morphology, longevity, and intimacy with the uterine endometrium. This review explores this diversity in the light of the evolution of viviparity, comparing the three main
Janet Rossant   +3 more
openaire   +4 more sources

Blastocyst metabolism

Reproduction, Fertility and Development, 2015
The mammalian blastocyst exhibits an idiosyncratic metabolism, reflecting its unique physiology and its ability to undergo implantation. Glucose is the primary nutrient of the blastocyst, and is metabolised both oxidatively and through aerobic glycolysis.
David K, Gardner, Alexandra J, Harvey
openaire   +3 more sources

Mechanics of blastocyst morphogenesis

Biology of the Cell, 2017
During pre‐implantation development, the mammalian zygote transforms into the blastocyst, the structure that will implant the embryo in the maternal uterus. Consisting of a squamous epithelium enveloping a fluid‐filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events.
J. Maître
openaire   +4 more sources

To blastocyst or not to blastocyst? That is the question

Human Reproduction, 2001
Recent advances in culture media preparations have allowed for cleavage embryos to be developed to the blastocyst stage. Blastocysts are regarded as having increased implantation potential, and two blastocysts are typically transferred, which reduces the occurrence of high order multiple gestations.
Peter Brinsden   +3 more
openaire   +3 more sources

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