Results 241 to 250 of about 455,319 (289)

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Assessing eye care behavior in rural India's traumatic cataract cases. [PDF]

Indian J Ophthalmol
Shah MA, Shah SM, Shah R, Balani N, Vador R, Rajoria V.   +5 more
europepmc   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Assessment of In-Frame Indel Variants in an Unsolved Cohort of Inherited Retinal Diseases Using Machine Learning. [PDF]

Hum Mutat
Rauch DE, Wang M, Hafiz MJH, Brock DC, Li Y, Marra M, Pennesi ME, Yang P, Lesley E, Lopez I, Koenekoop R, Collantes ER, Bolinao J, Chen R.   +13 more
europepmc   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Neglected tropical diseases: the need for an integrated approach to achieve the 2030 roadmap. [PDF]

Nat Commun
europepmc   +1 more source

Prevalence, burden, and determinants of visual impairment and blindness among adults in Saudi Arabia: a comprehensive systematic review and meta-analysis. [PDF]

BMC Ophthalmol
Khathami AA, Baklola M, Al-Bawah N, Alghamdi D, Shar NM, Alghamdi H, Alghamdi S, Alanazi N, Alalyani M, Hafez M, Alshomrani R, Ghaith K.   +11 more
europepmc   +1 more source

Blind Leading Blind

, 1974
openaire   +1 more source

Health care Experiences of Educated Young Adults With Blindness in the Digital Age: Qualitative Study.

J Med Internet Res
Zhao J, Su C, Zhu X, Cai C, Liu W, Ma X.
europepmc   +1 more source

Global, regional, and national trends in DALYs for blindness and vision loss in teenagers and young adults, 1990-2019: an age-period-cohort analysis based on the Global Burden of Disease Study 2019. [PDF]

Front Med (Lausanne)
Lu J, Jiang X, Yu H, Tian Y, Tao L.
europepmc   +1 more source