Results 61 to 70 of about 250,538 (263)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Prevalence and risk factors for diabetes and diabetic retinopathy: results from the Nigeria national blindness and visual impairment survey. [PDF]

, 2014
BACKGROUND: In Nigeria, urbanisation and increasing life expectancy are likely to increase the incidence of non-communicable diseases. As the epidemic of diabetes matures, visual loss from diabetic retinopathy (DR) will increase unless mechanisms for ...
Kyari, Fatima, Peto, Tunde; id_orcid, Murthy, Gudlavalleti VS, Fatima Kyari, Gudlavalleti VS Murthy, Gilbert, Clare E, Peto, Tunde, Tunde Peto, Tafida, Abubakar, Nigeria National Blindness and Visual Impairment Study Group, Sivasubramaniam, Selvaraj, Abubakar Tafida, Murthy, Gudlavalleti V S, Clare E Gilbert, Selvaraj Sivasubramaniam   +14 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Blindness and visual impairment due to retinal diseases. [PDF]

, 2009
This General Assembly, compared to others in the past, had retinal diseases as a cause of visual impairment and blindness higher up on the agenda. This article summarises the main points made in relation to retinal diseases, in particular the challenge ...
Shah, Shaheen, Shaheen Shah
core  

Color Blindness☆

, 2017
The scientific definition of color blindness is explained emphasizing that this denomination is not only applied to people without color experiences (monochromats) but also to people with uncommon color experiences (dichromats and anomalous trichromats).
Álvaro Llorente, Leticia, Julio A. Lillo, Leticia Álvaro, Humberto Moreira, Moreira Villegas, Humberto, Melnikova, Anna, Anna Melnikova, Lillo Jover, Julio Antonio   +7 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Priming for gender-blindness

, 2020
Access to thesis permanently restricted to Ball State community onlyWomen in traditionally male-typed domains tend to be evaluated more negatively than their male counterparts (Rudman, Moss-Racusin, Glick, & Phelan, 2012) due to persistent, deeply ...
Maric, Danka
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Myopia prevalence, refractive status and uncorrected myopia among primary and secondary school students in Germany

Frontiers in Medicine
IntroductionThe increasing prevalence of myopia worldwide is problematic because myopia can result in severe secondary pathologies, and is associated with considerable financial burden.
Astrid Hönekopp, Lisa-Marie Tommes, Philipp Doebler, Sarah Weigelt   +3 more
doaj   +1 more source