Results 71 to 80 of about 1,396,888 (382)

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

eLife, 2021
Disorders of the transparent cornea affect millions of people worldwide. However, how to maintain and/or regenerate this organ remains unclear. Here, we show that Rela (encoding a canonical NF-κB subunit) ablation in K14+ corneal epithelial stem cells ...
Qian Yu, Soma Biswas, Gang Ma, Peiquan Zhao, Baojie Li, Jing Li   +5 more
doaj   +1 more source

Detect the unexpected: a science for surveillance [PDF]

, 2008
Purpose – The purpose of this paper is to outline a strategy for research development focused on addressing the neglected role of visual perception in real life tasks such as policing surveillance and command and control settings. Approach – The scale of
Cronin, Patrick D. J., Scott-Brown, Kenneth C.   +1 more
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models

Journal of Pharmacological Sciences, 2009
KR-31378 is a newly developed KATP-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells (RGC), experiments were conducted using two retinal ischemia models.
Anho Choi, Jun-Sub Choi, Yone-Jung Yoon, Kyung-A Kim, Choun-Ki Joo   +4 more
doaj   +1 more source

Cortical plasticity and olfactory function in early blindness [PDF]

, 2017
Commentary: Cortical plasticity and olfactory function in early ...
Fiore, Alessandra, Pazzaglia, Mariella
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Myopia prevalence, refractive status and uncorrected myopia among primary and secondary school students in Germany

Frontiers in Medicine
IntroductionThe increasing prevalence of myopia worldwide is problematic because myopia can result in severe secondary pathologies, and is associated with considerable financial burden.
Astrid Hönekopp, Lisa-Marie Tommes, Philipp Doebler, Sarah Weigelt   +3 more
doaj   +1 more source

Physiological Mechanisms Underlying Motion-Induced Blindness [PDF]

, 2008
Visual disappearance illusions - such as motion-induced blindness (MIB) - are commonly used to study the neural underpinnings of visual perception. In such illusions a salient visual target becomes perceptually invisible.
Camilo Libedinsky, Margaret Livingstone, Tristram Savage   +2 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A Hospital Based Study Regarding Awareness of Association Between Glycosylated Haemoglobin and Severity of Diabetic Retinopathy in Type 2 Diabetic Individuals [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Diabetic retinopathy is one of the most common microvascular complications seen in diabetic patients after a long term of uncontrolled glycaemic status as assessed by glycosylated Haemoglobin A (HbA1c).
Mridula Prabhu, Anupama Kakhandaki, K.R. Pravin Chandra, M.B. Dinesh   +3 more
doaj   +1 more source