Results 71 to 80 of about 624,004 (359)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

BSL: Navigation Method Considering Blind Spots Based on ROS Navigation Stack and Blind Spots Layer for Mobile Robot [PDF]

IEEE Transactions on Industry Applications, vol. 60, no. 1, pp. 1695-1704, Jan.-Feb. 2024
This paper proposes a navigation method considering blind spots based on the robot operating system (ROS) navigation stack and blind spots layer (BSL) for a wheeled mobile robot. In this paper, environmental information is recognized using a laser range finder (LRF) and RGB-D cameras.
arxiv   +1 more source

Attention, Fixation, and Change Blindness [PDF]

, 2017
The topic of this paper is the complex interaction between attention, fixation, and one species of change blindness. The two main interpretations of the target phenomenon are the ‘blindness’ interpretation and the ‘inaccessibility’ interpretation.
Cheng, Tony
core   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Biosynthesis of fatty acids: IV. Studies with inhibitors

Journal of Lipid Research, 1963
Tetrolyl-CoA and propiolyl-CoA have been shown to be strong noncompetitive inhibitors of fatty acid synthesis. Acrylyl-CoA and isocrotonyl-CoA also inhibit, but much higher concentrations are required.
Joseph D. Robinson, Roscoe O. Brady, Roy M. Bradley   +2 more
doaj  

Myopia prevalence, refractive status and uncorrected myopia among primary and secondary school students in Germany

Frontiers in Medicine
IntroductionThe increasing prevalence of myopia worldwide is problematic because myopia can result in severe secondary pathologies, and is associated with considerable financial burden.
Astrid Hönekopp, Lisa-Marie Tommes, Philipp Doebler, Sarah Weigelt   +3 more
doaj   +1 more source

Double blinding-attack on entanglement-based quantum key distribution protocols [PDF]

, 2011
We propose a double blinding-attack on entangled-based quantum key distribution protocols. The principle of the attack is the same as in existing blinding attack except that instead of blinding the detectors on one side only, Eve is blinding the detectors of both Alice and Bob. In the BBM92 protocol, the attack allows Eve to get a full knowledge of the
arxiv   +1 more source

Culture and generalized inattentional blindness [PDF]

, 2006
A recent mathematical treatment of Baars' Global Workspace consciousness model, much in the spirit of Dretske's communication theory analysis of high level mental function, is used to study the effects of embedding cultural heritage on a generalized form
Wallace, Rodrick
core  

Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe [PDF]

, 2008
Toxoplasmic retinochoroiditis appears to be more severe in Brazil, where it is a leading cause of blindness, than in Europe, but direct comparisons are lacking.
Bahia-Oliveira, LM, Buffolano, W, European Multicentre Study on Congenital Toxoplasmosis (EMSCOT),, Freeman, K, Gilbert, RE, Lago, EG, Petersen, E, Stanford, MR, Tan, HK, Wallon, M   +9 more
core   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source