Results 111 to 120 of about 6,165,336 (284)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

A Reduced-Complexity Partial-Interference-Cancellation Group Decoder for STBCs

In this paper, we propose a reduced-complexity implementation of partial interference cancellation group decoder with successive interference cancellation (PIC-GD-SIC) by employing the theory of displacement structures.
Hari, K. V. S., Rajashekar, Rakshith, Hanzo, Lajos   +2 more
core   +1 more source

GLCSNet: A Building Change Detector With Global-Local Dual-Domain Awareness and Cross-Spatiotemporal Joint Modeling

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Building change detection (CD) in high-resolution remote sensing imagery is crucial for urban sustainable development, rapid disaster response, and environmental monitoring.
Hongyang Fan, Zhongmin Zhu, Wei Yang, Weitao Han   +3 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The changing typology of urban apartment buildings in Aurinkolahti

Buildings & Cities
This case study examines changes in apartment building layouts in the Aurinkolahti neighbourhood of metropolitan Helsinki, Finland, against the backdrop of rapid urban growth and shrinking apartment sizes.
Sanna Meriläinen, Anne Tervo
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Lightweight super-resolution reconstruction architecture of remote sensing images using a residual hierarchical transformer network

Scientific Reports
Remote Sensing image super-resolution technology aims to enhance spatial details, and it is of great significance for the high-quality interpretation of satellite imagery.
Bo Huang, Jian Lin, Qingtang Chen, Yiqing Cao, Liaoni Wu   +4 more
doaj   +1 more source

CaSaFormer: A cross- and self-attention based lightweight network for large-scale building semantic segmentation

International Journal of Applied Earth Observations and Geoinformation
Buildings play a crucial role in geographic information systems, and advancements in the resolution of remote sensing imagery have facilitated their extraction on a larger scale.
Jiayi Li, Yuping Hu, Xin Huang
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source