Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Protein-based custom-designed molecular nanotraps for biomedical applications. [PDF]
Maniglio D, Marinangeli A, Bossi AM.
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Algorithms for circuit layout compaction of building blocks
Compaction is the CAD tool used to pack rough sketches or symbolic diagrams to produce error free IC layouts. With the ever increasing complexity of VLSI circuitry, the building block approach becomes very important for custom VLSI design.
Varadarajan, Ramachandran
core
Output-Only Modal Identification of Civil Engineering Structures Based on Parametric Complexity Pursuit. [PDF]
Li J +4 more
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Stimulus complexity and retelling output in aphasia: an exploratory single-case analysis. [PDF]
Yoo H.
europepmc +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Name: Complexity Description: Complexity quantifies the range, interconnectedness, and adaptability of a system’s internal states. It reflects the diversity of the system's configurations, the degree of interaction among its components, and its potential
Gavin Short
core
An automated model for differential meet in the middle attacks on AndRX ciphers. [PDF]
Chakraborty D +3 more
europepmc +1 more source

