Results 61 to 70 of about 2,913,743 (333)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Applied SciencesIn this paper, we propose an enhanced clustering protocol that integrates an improved K-means with a Mobility-Aware Cluster Head-Election Scored (IK-MACHES) algorithm, designed for extending the lifetime and operational efficiency of Wireless Sensor ...
Cheolhee Yoon, Seongsoo Cho, Yeonwoo Lee
doaj +1 more source
Cooperative Communication Method Based on Block Chain for a Large Number of Distributed Terminals
IEEE Access, 2022 The cooperative communication of distributed terminals has many performance advantages and wide application prospects. However, it lacks effective trust foundation between distributed terminals and lacks data security guarantee. Block chain naturally has
Hui Zhi, Hongjie Ge, Yong Wang
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Enhancing supply chain efficiency through blockchain technology: A centralized multidistributor and multi-retailer approach [PDF]
Yugoslav Journal of Operations ResearchBlockchain technology has emerged as a transformative solution for supply chain management, offering a myriad of benefits to the industry. This paper explores the potential benefits of incorporating blockchain technology into supply chain management to ...
Motla Ritu +3 more
doaj +1 more source
Information Communications Technology Architecture and Implementation Scheme of Smart Energy System
发电技术, 2020 Based on social and economic development, environmental protection needs, industrial policy guidance and other factors, smart energy will bring a new round of tremendous changes to the traditional energy structure.
Tengbo DING, Hongbo LIU, Pin WU
doaj +1 more source
Analysis of the block chain use [PDF]
, 2019 The functioning of the block chain and its security is provided by miners and other block chain participants. Access to the block chain takes place using special keys that guarantee the reliability of the entire network.
Vishniakou, U. A., Khudier, R. K.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source