Results 81 to 90 of about 2,913,743 (333)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Data traceability mechanism based on consortium chain

网络与信息安全学报, 2023
With the unprecedented growth in the speed of data generation and circulation in the era of big data, the emergence of blockchain technology provides a new solution for data authenticity verification.However, with the increasing demand for data flow ...
Shoucai ZHAO, Lifeng CAO, Xuehui DU
doaj  

Block Chain

, 2017
The six chapters that follow provide an overview of the technology (chapter one) and its unfolding applications in emerging markets (chapter two). Chapter three examines whether blockchain can be used to mitigate de-risking by financial institutions. Chapters four and five look more closely at the financial services sector, including an overview of how
Niforos, Marina, Ramachandran, Vijaya, Rehermann, Thomas   +2 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Communication Between Vehicles Using Block Chain

, 2022
Communication modes are divided into two major segments in the form of Internet of Vehicles. Vehicle to Vehicle Communication known as V2V and Vehicle to Infrastructure Communication known as V2I.In both communication mode, vehicles has been able to ...
Shiva, Hari Hara
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

BLOCK CHAIN TECHNOLOGY

, 2021
Blockchain is a system of recording information in a way that it is not possible to change, hack, or cheat the system. Our data will be more secure using this technology. Blockchain is a type of DLT (Distributed Leger Technology) in which transactions are recorded with an immutable cryptographic signature called a hash.
openaire   +1 more source

Blocked and chained: Blockchain and the problems of transparency

Proceedings of the Association for Information Science and Technology, 2018
ABSTRACT Blockchain is frequently claimed to be a democratizing technology. However, its relationship to both law and broader democratic institutions remains uncertain. One claim regarding blockchain's democratic potential is that it is radically transparent and can bring such transparency to existing systems of governance. This paper
Darra L. Hofman, Alamir Novin
openaire   +1 more source

Corporate responsibility, supply chain partnership and performance: An empirical examination [PDF]

, 2012
This is the post-print version of the final paper published in International Journal of Production Economics. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections,
Ghobadian, A, Ghobadian, A., Gallear, D, Chen, Weifeng, Gallear, David, Chen, W., Weifeng Chen, David Gallear, Abby Ghobadian, Chen, W, Ghobadian, Abby, Gallear, D.   +11 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source