Results 81 to 90 of about 1,346,123 (313)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Analyzing spatial aggregation error in statistical models of late-stage cancer risk: a Monte Carlo simulation approach

open access: yesInternational Journal of Health Geographics, 2010
Purpose This paper examines the effect of spatial aggregation error on statistical estimates of the association between spatial access to health care and late-stage cancer.
Wang Fahui, McLafferty Sara, Luo Lan
doaj   +1 more source

The weight distribution and randomness of linear codes [PDF]

open access: yes
Finding the weight distributions of block codes is a problem of theoretical and practical interest. Yet the weight distributions of most block codes are still unknown except for a few classes of block codes.
Cheung, K.-M.
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Soft-decision decoding of some block codes [PDF]

open access: yes
The performance of certain binary block codes with soft-decision decoding is evaluated by simulation. A construction is proposed to introduce memory on block codes, and simulation results are shown for a trellis code derived from the Nordstrom-Robinson ...
Pollara, F.
core   +1 more source

Endomorphisms of Linear Block Codes

open access: yes2024 IEEE International Symposium on Information Theory (ISIT)
Accepted for presentation at International Symposium on Information Theory 2024; Included reviews: Changed some wordings, Indicate that 32,16 Polar code is a RM code; Smaller formatting changes, Results unchanged,
Mandelbaum, Jonathan   +3 more
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

On the undetected error probability of a concatenated coding scheme for error control [PDF]

open access: yes
Consider a concatenated coding scheme for error control on a binary symmetric channel, called the inner channel. The bit error rate (BER) of the channel is correspondingly called the inner BER, and is denoted by Epsilon (sub i). Two linear block codes, C(
Costello, D. J., Jr., Deng, H.
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Home - About - Disclaimer - Privacy