Results 81 to 90 of about 5,975,260 (378)
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
On the undetected error probability of a concatenated coding scheme for error control [PDF]
Consider a concatenated coding scheme for error control on a binary symmetric channel, called the inner channel. The bit error rate (BER) of the channel is correspondingly called the inner BER, and is denoted by Epsilon (sub i). Two linear block codes, C(
Costello, D. J., Jr., Deng, H.
core +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
, 1987 A Reed-Solomon decoder with dedicated hardware for five sequential algorithms was designed with overall pipelining by memory swapping between input, processing and output memories, and internal pipelining through the five algorithms.
Lahmeyer, Charles R.
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Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
BGRID: A block-structured grid generation code for wing sections [PDF]
The operation of the BGRID computer program is described for generating block-structured grids. Examples are provided to illustrate the code input and output.
Chen, H. C., Lee, K. D.
core +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
On the Many Faces of Block Codes
, 2000 Block codes are first viewed as finite state automata represented as trellises. A technique termed subtrellis overlaying is introduced with the object of reducing decoder complexity. Necessary and sufficient conditions for subtrellis overlaying are next derived from the representation of the block code as a group, partitioned into a subgroup and its ...
DESHMUKH, K +3 more
openaire +3 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source