Results 231 to 240 of about 46,823 (313)

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Synthesis and Self-Assembly of Pore-Forming Three-Arm Amphiphilic Block Copolymers. [PDF]

Macromol Rapid Commun
Pusse S, Niebuur BJ, Kraus T, Presser V, Balzer BN, Gallei M.   +5 more
europepmc   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Zwitterion-Stabilized Superlattices and Frank-Kasper Phases in Charged Block Copolymers for Mechanically Robust Dielectric Soft Materials. [PDF]

Adv Sci (Weinh)
Min J, Lee H, Park MJ.
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Chain Topology Engineering in Amphiphilic Block Copolymers: Crosslinking-Induced Nanodomain Refinement for Ultrahigh Energy Density under Extreme Conditions. [PDF]

Adv Sci (Weinh)
Zhai F, Xu L, Ye H.
europepmc   +1 more source

Multi‐Responsive Bowl‐Shaped Janus Nanomotors Based on Polyitaconic acid/Polypyrrole on the Surface of Iron Oxide Nanoparticles with Chemical, Electrical, and Magnetic Field Actuation for Targeted Drug Delivery Applications

Advanced NanoBiomed Research, EarlyView.
Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi, Sepideh Khoee, Shima Tavakoli, Oommen P. Varghese   +3 more
wiley   +1 more source

MWCNT Localization and Electrical Percolation in Thin Films of Semifluorinated PMMA Block Copolymers. [PDF]

Polymers (Basel)
Staudinger U, Janke A, Simon F, Jakisch L, Bittrich E, Formanek P, Mielke L, Schlicke H, Li Q, Eckstein K, Pospiech D.   +10 more
europepmc   +1 more source

Tailored Nanogel Network Topology Enables Clinical Ultrasound‐Induced Mechanochemical Activation for In Vivo Therapy

Angewandte Chemie, EarlyView.
The strategy of engineering nanogel network topology is developed to achieve iterative activation of mechanophores upon high‐frequency and low‐intensity ultrasound. This places the nanogel system among the systems that can respond to the ultrasound with the highest frequency and lowest intensity as well as have the fastest activation rate so far.
Helin Li, Fangyin Song, Xiaoye Hu, Li Jing, Qi Shuai, Weike Su, Andrij Pich, Xin Li   +7 more
wiley   +1 more source

Simplified Polymer Particle Design: Using Block Copolymers to Create Multihollow Structures. [PDF]

ACS Omega
Kamlangmak N, Rattanawongwiboon T, Minami H, Chaiyasat A.   +3 more
europepmc   +1 more source