Results 91 to 100 of about 2,940,629 (293)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Block 5 module design summary [PDF]

The Flat Plate Solar Array Block 5 Module design efforts of six manufacturers are summarized. Residential designs and module designs for intermediate-load applications are described.
Runkle, L. D.
core   +1 more source

Temperature-stabilized, triggerable microelectronic astable multivibrator starts reliably [PDF]

, 1967
Multiple chip custom block, MIC construction is used to fabricate an ultracompact, low-power astable multivibrator. The design provides a multivibrator that free runs, eliminating lockup, is triggerable, pulling into synchronization with an external ...
Stebbins, W. J.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The twisted Grassmann graph is the block graph of a design

, 2009
In this note, we show that the twisted Grassmann graph constructed by van Dam and Koolen is the block graph of the design constructed by Jungnickel and Tonchev.
Munemasa, Akihiro, Tonchev, Vladimir D.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The effect of colour on students' learning experience and creativity in design schools

Creativity Studies
Research indicates that colours used in learning environments can influence student performance in terms of creativity. However, the impact of different shades of classroom walls affect students’ learning experience regarding creativity and willingness ...
Shanta Pragyan Dash, Varshini Vittal
doaj   +1 more source

http://jestec.taylors.edu.my/Vol%2011%20issue%2012%20December%202016/11_12_2.pdf [PDF]

Journal of Engineering Science and Technology, 2016
Worldwide interoperability for microwave access (WiMAX) or the IEEE 802.16 standard for broadband Internet access as well as metro-wide wireless sensor network (WSN) communication, continues to gain popularity as a technology with a significant market ...
R. AHMAD, W. ISMAIL
doaj