Results 131 to 140 of about 113,837 (311)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Trend-resistant and cost-efficient cross-over designs for mixed models. [PDF]
A mixed model approach is used to construct optimal cross-over designs. In a cross-over experiment the same subject is tested at different points in time.
Tack, L, Vandebroek, Martina
core
Inner balance of symmetric designs
, 2014 A triple array is a row-column design which carries two balanced incomplete block designs (BIBDs) as substructures. McSorley et al. (Des Codes Cryptogr 35: 21–45, 2005), Section 8, gave one example of a triple array that also carries a third BIBD, formed
Heidtmann, Pia, +3 more
core +1 more source
Copula-based robust optimal block designs. [PDF]
Appl Stoch Models Bus Ind, 2020 Rappold A, Müller WG, Woods DC.
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Standard Block and Modular Dwelling Designs in Hong Kong’s Public Housing
ArchitectureThis paper examines the role of standard block and modular dwelling designs in Hong Kong’s public housing provision since the mid-1950s. It explores how standard types have evolved in relation to housing policies, demographic and socio-economic changes ...
Lu Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Block-decomposable divisible designs
, 2005 Titel und Inhalt Einleitung xi 1\. Grundlagen 1 1.1 Einige Inzidenzstrukturen 1 2\. Block-Zerlegbarkeit divisibler Designs 12 2.1 Das Konzept der Block-Zerlegbarkeit 12 2.2 Identifikation block-zerlegbarer divisibler Designs 17 2.3 ...
Giese, Sabine
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source