Results 81 to 90 of about 331,300 (260)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A note on the computation of the bit error rate for binary block codes

Linear Algebra and its Applications, 1988
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Meta deep reinforcement learning-based link adaptation method for cellular networks

Tongxin xuebao
To address the stringent requirements for reliability and data rate in cellular networks, an efficient and highly generalizable link adaptation method was proposed.
Ye Xiaowen, Lin Hengyi, Wu Yi
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Meta Deep Reinforcement Learning-Based Link Adaptation for Cellular Networks

Tongxin xuebao
To address the stringent requirements for reliability and data rate in cellular networks, an efficient and highly generalizable link adaptation method was proposed.
YE Xiaowen, LIN Hengyi, WU Yi
doaj  

Joint Noniterative Beamforming Schemes for BER Minimization in Next-Generation Wireless Sensor Networks

Journal of Electrical and Computer Engineering
This research paper proposes three joint transmit and receive (TX/RX) beamforming schemes for minimizing the bit error rates of next-generation wireless sensor networks. Based on minimizing the optimization problem of the total mean squared error between
Mohamed S. Abouzeid, Heba A. El-Khobby, Mahmoud A. A. Ali, Mohamed E. Nasr   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Double symbol error rate and block error rate of MDPSK

Double symbol error rate and block error rate of MDPSK
The double symbol error rate (DSER) is calculated for an M-ary DPSK (MDPSK) system to show that double symbol errors are less likely to be produced when M>or=4 than for the binary case (M=2) and that MDPSK with M>or=4 provides similar conditional SER (defined as the SER when the previous symbol decision was in error) when compared at the same SER value.
openaire