Results 61 to 70 of about 1,411,285 (285)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An optimized transform and quantization scheme for HEVC intra lossless coding

Engineering Reports
The lossless coding framework of High Efficiency Video Coding (HEVC) comprises prediction and entropy coding, while omitting the transform process. However, residuals derived from prediction continue to demonstrate significant spatial redundancy, which ...
Xiaojie Liu, Linqi Yan, Yang Zhang, Gang Ren, Mingdong Zhu   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exact Evaluation of Block-Error Rate Using Correct Probability for Space-Time Codes [PDF]

2007 IEEE International Symposium on Information Theory, 2007
Union bound based on pair-wise error probability (PEP) has been widely used for error-rate performance evaluation of space-time (S-T) codes. At low signal-to-noise ratios (SNRs), the PEP is not very accurate, leading to a loose union bound. A numerical integration method using correct probability is proposed in this paper for the evaluation of block ...
Zhang, Z, Yuk, TI, Cheung, SW
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Order Statistics Based List Decoding Techniques for Linear Binary Block Codes [PDF]

, 2011
The order statistics based list decoding techniques for linear binary block codes of small to medium block length are investigated. The construction of the list of the test error patterns is considered.
Alnawayseh, Saif E. A., Loskot, Pavel
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Multilevel Coded Modulation for Unequal Error Protection and Multistage Decoding—Part I: Symmetric Constellations [PDF]

, 1999
In this paper, theoretical upper bounds and computer simulation results on the error performance of multilevel block coded modulations for unequal error protection (UEP) and multistage decoding are presented.
Hideki Imai, Marc P. C. Fossorier, Motohiko Isaka, Robert H. Morelos-Zaragoza, Shu Lin   +4 more
core   +5 more sources

Polar codes for the two-user multiple-access channel

, 2010
Arikan's polar coding method is extended to two-user multiple-access channels. It is shown that if the two users of the channel use the Arikan construction, the resulting channels will polarize to one of five possible extremals, on each of which uncoded ...
Sasoglu, Eren, Telatar, Emre, Yeh, Edmund   +2 more
core   +1 more source