Results 61 to 70 of about 331,300 (260)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Upper bound for block-error rate of S-T codes
Electronics Letters, 2007 A novel upper bound is proposed using correct probability for evaluation of block-error rate of space-time codes at low signal-to-noise ratio. Analytical and numerical results show that, at low SNR, the proposed bound is tighter and more accurate than that of the Union Bound using the pair-wise error probability.
Yuk, TI, Zhang, Z, Cheung, SW
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IEEE AccessPolar codes are one of the most powerful types of forward error correction codes. These codes are now adopted in the 5G standard for control channels and are the primary contender for future communication systems.
Mai Adel +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Algorithm for Frame Rate up Conversion Based on Verification Block and Verification Frames
工程科学与技术, 2013 : In this paper, we discuss Frame Rate up Conversion .Many algorithm for frame rate up conversion have been presented, but none of them make full use of the information of image to estimate the motion vector of insert block.
Zhang Ying-Ying
doaj
Performance Simulation of a Layered QC-LDPC Decoder for URLLC Applications [PDF]
EPJ Web of ConferencesThis research investigates the simulation performance of a layered Quasi-Cyclic Low-Density Parity-Check (QC-LDPC) decoder intended for Ultra-Reliable Low-Latency Communication (URLLC) applications in 5G New-Radio (NR) standards.
Mejmaa Bilal +3 more
doaj +1 more source