Results 51 to 60 of about 331,300 (260)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Janus compatible software-defined underwater acoustic multiple-input multiple-output modem
International Journal of Distributed Sensor Networks, 2021 This article describes the implementation of a multiple-input multiple-output acoustic communication link in shallow water conditions to enable a software-defined acoustic modem with a maximum transmission rate of 20 kbps in a 5-kHz bandwidth.
Surinder Singh +3 more
doaj +1 more source
Exact Evaluation of Block-Error Rate Using Correct Probability for Space-Time Codes [PDF]
2007 IEEE International Symposium on Information Theory, 2007 Union bound based on pair-wise error probability (PEP) has been widely used for error-rate performance evaluation of space-time (S-T) codes. At low signal-to-noise ratios (SNRs), the PEP is not very accurate, leading to a loose union bound. A numerical integration method using correct probability is proposed in this paper for the evaluation of block ...
Zhang, Z, Yuk, TI, Cheung, SW
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Dianxin kexue, 2015 Congestion control algorithms of TCP protocol previously used in space communications are mostly based on TCP Vegas algorithm.They always require accurately measurement of RTT,but it's very difficult to achieve in deep space communication networks which ...
Junrong Yan, Yulong Lu, Peng Pan
doaj +2 more sources
Waveform Design for Dual-Function Radar-Communication System With Golay Block Coding
IEEE Access, 2019 In view of the defects that high range side lobes and high peak-to-average power radio (PAPR) in radar and communication integrated systems based on traditional orthogonal frequency division multiplexing (OFDM), a co-designed OFDM waveform based on Golay
Wanlu Li, Zheng Xiang, Peng Ren
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source