Results 101 to 110 of about 535,226 (278)

Accurate Computations with Block Checkerboard Pattern Matrices

Mathematics
In this work, block checkerboard sign pattern matrices are introduced and analyzed. They satisfy the generalized Perron–Frobenius theorem. We study the case related to total positive matrices in order to guarantee bidiagonal decompositions and some ...
Jorge Delgado, Héctor Orera, J. M. Peña   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Block Preconditioned SSOR Methods for -Matrices Linear Systems

Journal of Applied Mathematics, 2013
We present a block preconditioner and consider block preconditioned SSOR iterative methods for solving linear system . When is an -matrix, the convergence and some comparison results of the spectral radius for our methods are given.
Zhao-Nian Pu, Xue-Zhong Wang
doaj   +1 more source

Spectral Properties of Block Jacobi Matrices [PDF]

Constructive Approximation, 2018
We study the spectral properties of bounded and unbounded Jacobi matrices whose entries are bounded operators on a complex Hilbert space. In particular, we formulate conditions assuring that the spectrum of the studied operators is continuous. Uniform asymptotics of generalised eigenvectors and conditions implying complete indeterminacy are also ...
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Representations for the Drazin inverses of block matrices

MATEC Web of Conferences, 2016
In this paper, we investigate representations of the Drazin inverse of a 2 × 2 block matrix. The Drazin inverse of a matrix is very important in various applied mathematical fields like machinery and automation, singular differential equations. We give a
Guo Li, Wang Jie, Du Wenming
doaj   +1 more source

MATRIX SUBADDITIVITY INEQUALITIES AND BLOCK-MATRICES [PDF]

International Journal of Mathematics, 2009
We give a number of subadditivity results and conjectures for symmetric norms, matrices and block-matrices. Let A, B, Z be matrices of same size and suppose that A, B are normal and Z is expansive, i.e. Z*Z ≥ I. We conjecture that [Formula: see text] for all non-negative concave function f on [0,∞) and all symmetric norms ‖ · ‖ (in particular for all ...
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source