Results 101 to 110 of about 1,500,614 (287)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
LSB-based pre-embedding video steganography with rotating & shifting poly-pattern block matrix. [PDF]
PeerJ Comput Sci, 2022 Hacimurtazaoglu M, Tutuncu K.
europepmc +1 more source
Jost asymptotics for matrix orthogonal polynomials on the real line
, 2011 We obtain matrix-valued Jost asymptotics for block Jacobi matrices under an L1-type condition on Jacobi parameters, and give a necessary and sufficient condition for an analytic matrix-valued function to be the Jost function of a block Jacobi matrix with
Kozhan, Rostyslav
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Zhejiang Daxue xuebao. Lixue ban, 2018 Based on the existing algorithms,we further study relaxed modulus-based synchronous block multisplitting multi-parameters methods for linear complementarity problem. Furthermore, we give the weaker convergence results of our new method in this paper when
ZHANGLitao(张理涛) +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Consistent Block Diagonal and Exclusive Multi-view Subspace Clustering [PDF]
Jisuanji kexueSubspace clustering method provides an effective solution to the clustering problem of high-dimensional multi-view data.Focusing on the issue that the representation matrix cannot obey the block diagonal property directly by using low rank or sparse ...
WU Jie, WAN Yuan, LIU Qiujie
doaj +1 more source