Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
An extension of the block spacial path approach to analysis of the influence of intra and interregional trade on multiplier effects in general interregional input-output models [PDF]
In a number of recent papers Sonis, Hewings and coworkers have extended spacial path analysis to a block structural context capable of analysing the relationship between direct blocks of influence, such as intra and interregional trade coefficients or ...
Russel Cooper
core
Secure Key Exchange in Tropical Cryptography: Leveraging Efficiency with Advanced Block Matrix Protocols [PDF]
Mariana Durcheva, Kiril Danilchenko
openalex +3 more sources
High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2) [PDF]
, 2014 Kulrut Borrirukwanit +4 more
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Computation of Invariant Measures and Stationary Expectations for Markov Chains with Block-Band Transition Matrix [PDF]
, 2020 Hendrik Baumann, Thomas Hanschke
openalex +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Block incomplete factorization preconditioners for a symmetric block-tridiagonal M-matrix
Journal of Computational and Applied Mathematics, 1998 New block incomplete factorization preconditioners are introduced for a symmetric block-tridiagonal \(M\)-matrix. Parallel computations and the main properties including spectral properties of the method are analysed.
openaire +2 more sources
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source