Results 121 to 130 of about 1,389,504 (295)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
JCA AdvancesStudy objective: To evaluate the diagnostic accuracy and feasibility of the swirl sign, a novel bedside visual adjunct, for confirmation of epidural catheter placement. Design: Prospective, randomized, parallel-group pilot diagnostic study.
Gautham Patel, MD, DNB +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Estimating Climate Risk Exposure in the U.S. Insurance Sector Using Factor Model and EVT
MathematicsThis study examines the exposure of the U.S. insurance sector to climate-related risks using a two-step approach combining factor modeling and Extreme Value Theory. The analysis first constructs a climate risk factor from transition-sensitive sectors and
Olanrewaju Oluwadamilare Olaniyan
doaj +1 more source
High Resolution Ozone Mapper (HROM) [PDF]
Using the backscatter ultraviolet instrument (BUV) aboard NIMBUS 4 as a baseline, point scanner mechanisms and spatial multiplex scanning systems were compared on the basis of sensitivity, field of view and simplicity.
Decker, J., Kohr, J. R., Wegant, R.
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A New Test (Blocking Test) for Rh Sensitization.
Experimental Biology and Medicine, 1944 As was first shown by Wiener and Peters,1 sensitization of Rh-negative individuals against the Rh factor can often be detected by in vitro tests for anti-Rh agglutinins in the individual’s plasma. However, it was soon found2,3 that there are many Rh-negative patients who are strongly sensitized to the Rh factor, as proved by the occurrence of an ...
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source