Results 131 to 140 of about 4,772 (272)

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, Volume 21, Issue 1, January 2026.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

A comparative study of AI and human programming on environmental sustainability. [PDF]

Sci Rep
Woo NH.
europepmc   +1 more source

Designing a Sensible Block Semi-Random Interleaver for Turbo Codes

, 2016
Md. Nahidul, Md. Rakibul, Mahmudul Hasan, O Ohidujjaman   +3 more
openalex   +1 more source

A Shock‐Tube Facility for Gas‐Phase Chemical Kinetics Studies: Design, Validation, and Application for Methane Oxidation

Chemistry–Methods, Volume 6, Issue 1, January 2026.
A high‐pressure shock‐tube facility is developed to investigate high‐temperature chemical‐kinetics for next‐generation combustion systems. The design enables extended test times and integrates multiple optical diagnostics for time‐resolved species detection.
Sulaiman A. Alturaifi, Belal Y. Belal, Ali Elkhazraji, Obaidallah Muntashari, Awad. B. S. Alquaity, Mohamed A. Alya, Khair Ghunaim, Yasser S. Omer, Mahmoud E. Hasan   +8 more
wiley   +1 more source

Exit chart applied to frequency domain turbo equalization for single carrier space-time block code per block

, 2009
Patricia Armando, Karine Amis, Dominique Roux   +2 more
openalex   +1 more source

Study of the block and convolutional code decoding efficiency using a turbo code decoder [PDF]

Alexander A Sidorenko
openalex   +1 more source

Engineered Leaf‐Branch Compost Cutinase with Enhanced PET Degradation Across a Broad Temperature Range

ChemSusChem, Volume 19, Issue 1, January 2026.
This study aimed to identify poly(ethylene terephthalate) (PET)‐degrading enzymes effective under industrially relevant conditions. An engineered leaf and branch compost cutinase variant showed enhanced PET hydrolysis across multiple temperatures, outperforming existing enzymes.
Kavita G. Ramnath, Colin T. Pierce, Guillem Casadevall, Silvia Osuna, Jadyn Ide‐Pech, Bryan Zeng, Vishnu Iyer, Romas J. Kazlauskas, Richard A. Gross   +8 more
wiley   +1 more source

Leveraging large language models for data analysis automation. [PDF]

PLoS One
Jansen JA, Manukyan A, Al Khoury N, Akalin A.   +3 more
europepmc   +1 more source

Evolution of Plasticity in Response to Ethanol Between Recently Separated Populations of D. melanogaster With Different Ecological Histories

Ecology and Evolution, Volume 16, Issue 1, January 2026.
We identified: (1) differences in gene expression among each locale; (2) changes in gene expression in response to treatment; (3) genotype‐specific changes in gene expression in response to treatment. ABSTRACT While there is abundant theoretical work on the evolution of phenotype plasticity, empirical support has lagged.
George Boateng‐Sarfo, Franz Scherping, Murad Mammadov, Sarah Signor   +3 more
wiley   +1 more source

Large language models reflect the ideology of their creators. [PDF]

NPJ Artif Intell
Buyl M, Rogiers A, Noels S, Bied G, Dominguez-Catena I, Heiter E, Johary I, Mara AC, Romero R, Lijffijt J, De Bie T.   +10 more
europepmc   +1 more source