Results 241 to 250 of about 330,080 (279)

Facilitating DNAzyme transport across the blood-brain barrier with nanoliposome technology. [PDF]

Sci Rep
Hoseinifar MJ, Aghaz F, Asadi Z, Asadi P, Nedaei SE, Arkan E, Pourmotabbed A, Bahrami G, Pourmotabbed T.   +8 more
europepmc   +1 more source

Immunolocalization of Heat Shock Protein after Fluid Percussive Brain Injury and Relationship to Breakdown of the Blood-Brain Barrier

, 1993
Hirokazu Tanno, Russ P. Nockels, Lawrence H. Pitts, Linda J. Noble‐Haeusslein   +3 more
openalex   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Blood-Brain Barrier (BBB) Dysfunction in CNS Diseases: Paying Attention to Pericytes. [PDF]

CNS Neurosci Ther
Yu T, Wang Z, Chen Y, Xiang Y, Wu M, Zhang M, Yin X, Chen Z.   +7 more
europepmc   +1 more source

Protein synthesis at the blood-brain barrier. The major protein secreted by amphibian choroid plexus is a lipocalin

, 1992
Marc G. Achen, Paul J. Harms, Tim Thomas, Samantha J. Richardson, Richard E.H. Wettenhall, Gerhard Schreiber   +5 more
openalex   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Identification and Characterization of a Translational Mouse Model for Blood-Brain Barrier Leakage in Cerebral Small Vessel Disease. [PDF]

Int J Mol Sci
Jia R, Solé-Guardia G, Verweij V, Snabel JM, Geenen B, Tuladhar AM, Kleemann R, Kiliaan AJ, Wiesmann M.   +8 more
europepmc   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Understanding the blood brain barrier: current state and therapeutic implications. [PDF]

EBioMedicine
eBioMedicine.
europepmc   +1 more source

In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage

Advanced Science, EarlyView.
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang, Peisen Yao, Fuxiang Chen, Shufa Zheng, Xuegang Niu, Haojie Wang, Yuanxiang Lin, Bin Gao, Dezhi Kang   +8 more
wiley   +1 more source