Results 251 to 260 of about 330,080 (279)

Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease. [PDF]

Nature
Shi SM, Suh RJ, Shon DJ, Garcia FJ, Buff JK, Atkins M, Li L, Lu N, Sun B, Luo J, To NS, Cheung TH, McNerney MW, Heiman M, Bertozzi CR, Wyss-Coray T.   +15 more
europepmc   +1 more source

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Assessing blood-brain barrier (BBB) integrity in an Alzheimer's disease mouse model: is the BBB globally or locally disrupted? [PDF]

Fluids Barriers CNS
Nozohouri E, Noorani B, Patel D, Ahn Y, Zoubi S, Bickel U.   +5 more
europepmc   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Computational Modeling of Pharmaceuticals with an Emphasis on Crossing the Blood-Brain Barrier. [PDF]

Pharmaceuticals (Basel)
Alves PA, Camargo LC, Souza GM, Mortari MR, Homem-de-Mello M.   +4 more
europepmc   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Carotid endarterectomy and blood-brain barrier permeability in subjects with bilateral carotid artery stenosis. [PDF]

Chin Neurosurg J
Lu C, Zhu C, Li W, Zhu H, Zhang Q, Liu T, Yang T, Zhang Y.   +7 more
europepmc   +1 more source

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Advanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch, Roberto De Luca, Richard L Spinieli, Enrico Rillosi, Renner C Thomas, Samuel Sailesh, Nishta Gangeddula, Janayna D Lima, Sathyajit S Bandaru, Elda Arrigoni, Agustin Melo‐Carrillo, Rami Burstein, Stephen Thankachan, Satvinder Kaur   +13 more
wiley   +1 more source

Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain. [PDF]

mSphere
Fukuta M, Fukano S, Maekawa N, Kobayashi S, Okamoto S, Hirano M, Nio-Kobayashi J, Kariwa H, Kawakami S, Konnai S, Yoshii K.   +10 more
europepmc   +1 more source