Results 261 to 270 of about 700,460 (319)

Regional heterogeneity of the blood-brain barrier. [PDF]

Nat Commun
Blanchette M, Bajc K, Gastfriend BD, Profaci CP, Ruderisch N, Dorrier CE, Zhong G, Cuevas-Diaz Duran R, Harvey SS, Garcia-Pak IH, Pintarić L, Leclerc M, Reveret L, Émond V, Wang A, Pant D, Tsai LT, Calon F, Isoherranen N, Palecek SP, Shusta EV, Wu J, Daneman R.   +22 more
europepmc   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Selective Head Cooling and NOX Inhibition Protect the Blood-Brain Barrier in Neonatal Epilepsy. [PDF]

Antioxidants (Basel)
Parfenova H, Liu J, Basuroy S, Zhang R, Harsono M, Pourcyrous M.   +5 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Drug-Dependent Enhancement of Blood-Brain Barrier Permeation by Polysorbate 80 Minor Components. [PDF]

Pharmaceutics
Wang X, Wang J, Zhao X, Xie L, Yang R, Sun C, Tu J, Sun H.   +7 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Blood-brain barrier integrity and prevalence of intrathecal T helper 17.1 cells in Huntington´s disease. [PDF]

PLoS One
Ásbjörnsdóttir B, Musaeus CS, Hellem MNN, Vinther-Jensen T, Ejlerskov P, Budtz-Jørgensen E, Qvist FL, Simonsen AH, Hjermind LE, Skotte NH, von Essen MR, Sellebjerg F, Nielsen JE.   +12 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source