Results 51 to 60 of about 674,412 (272)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Blood-brain- barrier co-culture models to study nanoparticle penetration : focus on co-culture systems [PDF]

, 2015
The blood-brain barrier, as a physical, active transport and metabolic barrier represents the main obstacle in the treatment of central nervous system diseases.
Bocsik, Alexandra, Deli, Mária Anna, Hantosi, Dóra, Veszelka, Szilvia, Walter, Fruzsina R.   +4 more
core  

Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors [PDF]

, 2009
Systemic chemotherapy has been relatively ineffective in the treatment of malignant brain tumors even though systemic chemotherapy drugs are small molecules that can readily extravasate across the porous blood-brain tumor barrier of malignant brain tumor
Hemant Sarin, DN Louis, JS Barnholtz-Sloan, LJ Schouten, M Brown, A Wohrer, JB Posner, SS Brem, LA Stewart, MG Ewend, T Ranjan, T Stafinski, J Lutterbach, ES Nussbaum, ER Laws, R Stupp, ST Chao, R Stupp, FJ Lagerwaard, RA Patchell, K Jellinger, WR Shapiro, M Brada, WKA Yung, R Stupp, G Lanzetta, D Thomas, R Soffietti, NH Greig, FM Iwamoto, C Kosmas, R Stupp, NH Greig, LL Muldoon, AT Nies, NA Vick, DR Groothuis, M Essig, G Schneider, VA Levin, VA Levin, NH Greig, DJ Begley, WR Shapiro, HB Newton, H Nakagawa, B Zunkeler, SI Rapoport, VT Oliverio, RA Bender, L Slordal, R Preiss, B Rosenberg, ES Newlands, MG Donelli, DF Emerich, K Warren, HD Thomas, H Sarin, K Warren, IJ Dunkel, IJ Dunkel, F Vargas, CA Lipinski, R Langer, H Maeda, JS Lengyel, A Bootz, O Veiseh, B Sanchez De Juan, US Sharma, T Siegal, H Sarin, H Sarin, JD Fenstermacher, MW Brightman, MW Brightman, RR Bruns, CC Michel, J Folkman, J Folkman, RK Jain, WG Roberts, NA Vick, H Hashizume, KE Schlageter, SC Satchell, AA Sousa, K Asotra, H Hasegawa, P Molnar, WL Monsky, PS Tofts, MC Ferrier, EM Haacke, AR Pries, S Weinbaum, JM Squire, FE Curry, D Chappell, LL Muldoon, G Nilaver, RH Adamson, CBS Henry, AS Lossinsky, RB Campbell, M Dellian, WM Saltzman, HP Kalofonos, J Li, R Müller, CL Jackson, H Soo Choi, HC Roberts, R Jain, GA Lutty, HD Herce, S Thaler, SK Hobbs, F Yuan, A Mecke, CC Lee, RS Greenfield, Y Moriyama, K Kono, P Vaupel, J Carmichael, M Jeansson, RF Barth, Q Xie, W Yang, DY Arifin, WA Hall, W Yang, F Alam, J Capala, W Yang   +136 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Investigation of Lysophospholipids-DHA transport across an in vitro human model of blood brain barrier

Heliyon
Several studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases.
Mayssa Hachem, Abdelmoneim H. Ali, Ibrahim Yildiz, Christophe Landry, Fabien Gosselet   +4 more
doaj   +1 more source

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Pharmaceutics, 2020
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier.
Ambre Dauba, Anthony Delalande, Hermes A. S. Kamimura, Allegra Conti, Benoit Larrat, Nicolas Tsapis, Anthony Novell   +6 more
doaj   +1 more source

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2009
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane, Bangsow, Thorsten, Corada, Monica, Czupalla, Cathrin Jacqueline, Dejana, Elisabetta, Felici, Angelina, Fruttiger, Marcus, Gerhardt, Holger, Liebner, Stefan, Melchner, Harald von (Prof. Dr.), Plate, Karl H., Reis, Marco, Taddei, Andrea, Taketo, Makoto Mark, Wolburg, Hartwig   +14 more
core  

Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility [PDF]

, 2018
Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear.
Anthony, D C, Consentino Kronka Sosthenes, M, Couch, Y, Evans, M C, Roodselaar, J, Stolp, H B, Sá-Pereira, I   +6 more
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Pharmaceutics
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption.
Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N. Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza   +10 more
doaj   +1 more source