Results 91 to 100 of about 51,112 (243)

Reports of Lipoptena fortisetosa on dogs and in the environment, and evidence of its widespread establishment in Hungary

International Journal for Parasitology: Parasites and Wildlife
Lipoptena fortisetosa is a louse fly of East Asian origin that is considered a potential vector of several pathogenic bacteria and is most commonly associated with deer (Cervidae).
Adrienn Gréta Tóth, Attila Bende, Sándor Hornok, Zsombor Wagenhoffer, Balázs Szulyovszky, Viktória Galla, Petra Vöröskői, Gergő Keve   +7 more
doaj   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Comprehensive study of ticks and tick-borne diseases in dogs in Nepal: molecular identification, risk analysis and hematological alterations

BMC Veterinary Research
Background Ticks are responsible for the transmission of various viral, bacterial, and protozoal pathogens through their mouthparts while feeding on the blood of the host.
Somnath Aryal, Rebanta Kumar Bhattarai, Kamana Thapa   +2 more
doaj   +1 more source

Characterization of the Blood Bacterial Microbiota in Lowland Tapirs (Tapirus terrestris), a Vulnerable Species in Brazil

Microorganisms
Microbiome studies targeting hypervariable regions of the 16S rRNA gene are suitable for understanding interactions between animals and their associated bacteria.
Anna Claudia Baumel Mongruel, Emília Patrícia Medici, Rosangela Zacarias Machado, Keith Clay, Marcos Rogério André   +4 more
doaj   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Blood-Borne Pathogens in Emergency Medicine [PDF]

Annals of Emergency Medicine, 2017
openaire   +2 more sources

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

The bacterial patterns suggesting the dynamic features of tick-associated microorganisms in hard ticks

BMC Microbiology
Background Ticks are blood-feeding significant arthropods that can harbour various microorganisms, including pathogens that pose health risks to humans and animals.
Bin Xu, Mengjie Gu, Qunfeng Wu, Chang Shu, Wenbo Tan, Suwen Wang, Zhengwei Zhong, Xiaoling Wang, Jian Li, Jingwen Wang, Yuanzhi Wang, Wei Hu   +11 more
doaj   +1 more source

Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal‐Immunotherapy

Advanced Science, EarlyView.
Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang, Shanshan Liang, Meng Wang, Tingfeng Zhang, Jinke Liu, Yuyuan Peng, Hao Fang, Lingna Zheng, Xiao He, Meng Wang, Luling Wu, Tony D. James, Wei Zhao, Bing Wang, Weiyue Feng   +14 more
wiley   +1 more source