Results 211 to 220 of about 117,110 (303)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Ticks: Biology, Habitat, Threats and Protection Methods. [PDF]

Biology (Basel)
Szalata M, Wielgus K, Danielewski M, Hnatyszyn A, Szalata M, Skrzypczak-Zielińska M, Słomski R.   +6 more
europepmc   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Evaluation of platelet surface-associated immunoglobulin positivity and its association with hematologic findings and vector-borne pathogens in thrombocytopenic dogs. [PDF]

J Vet Intern Med
Boontuboon W, Sakcamduang W, Osathanon R, Nedumpun T, Srimontri P.   +4 more
europepmc   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Epidemiological Investigation and Phylogenetic Analysis of Major Blood-Derived Pathogens in Sheep from Gansu Province. [PDF]

Pathogens
Luo J, Ma L, Xiao F, Obaid MK, Zheng H, Ren Q, Guan G, Yin H, Liu P.   +8 more
europepmc   +1 more source

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Investigation and Correlation Analysis of Pathogens Carried by Ticks and Cattle in Tumen River Basin, China. [PDF]

Vet Sci
Min P, Song J, Meng Y, Zhao S, Tang Z, Wang Z, Lin S, Zhao F, Liu M, Wang L, Jia L.   +10 more
europepmc   +1 more source

Clinical Insights From a Case of Sifrim‐Hitz‐Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT To enhance clinicians' understanding of Sifrim‐Hitz‐Weiss syndrome (SIHIWES), this study investigated the clinical phenotypes, genetic characteristics, and response to growth hormone therapy in a patient. A case of a patient with global developmental delay and distinctive facial features is presented.
Jianmei Zhang, Shuangzhong Chen, Guanping Dong, Suhong Yang, Ping Wang, Qiong Zhou, Pingping Wang   +6 more
wiley   +1 more source

Pathogen screening of Zambian ticks: new insights on the occurrence of tick-borne pathogens in the country. [PDF]

Parasit Vectors
Makayi C, Simainga S, Mertens-Scholz K, Chitimia-Dobler L, Fischer S, Labruna MB, Mans BJ, Dautu G, Brangsch H, Simuunza M, Groschup MH, Schulz A.   +11 more
europepmc   +1 more source