Results 1 to 10 of about 46,320 (265)
Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis
Acta Pharmaceutica Sinica B, 2023 The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) in autophagy and the pathogenesis of diet-induced steatohepatitis in mice ...
ZHAOHUI LIU, Tipoe George, Jia Xiao
exaly +7 more sources
Circulation Research, 2019 Supplemental Digital Content is available in the text.
Jane A Mitchell +2 more
exaly +7 more sources
The Carboxyl-terminal End of Cox1 Is Required for Feedback Assembly Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria [PDF]
Journal of Biological Chemistry, 2010 Synthesis of the largest cytochrome c oxidase (CcO) subunit, Cox1, on yeast mitochondrial ribosomes is coupled to assembly of CcO. The translational activator Mss51 is sequestered in early assembly intermediate complexes by an interaction with Cox14 that depends on the presence of newly synthesized Cox1. If CcO assembly is prevented, the level of Mss51
Thomas D Fox, Xochitl Perez-Martinez
exaly +3 more sources
Cyclooxygenase 1 (COX1) as an indicator of sperm quality in humans
Andrologia, 2020 Sperm quality is important for in vitro fertilisation and embryo transfer and intracytoplasmic sperm injection in the treatment of human infertility. The purpose of this study was to screen for biomarkers that could evaluate sperm quality.
Yongjie Liu, Fan Zhang, L. Dai
semanticscholar +3 more sources
Deep RNA sequencing reveals the smallest known mitochondrial micro exon in animals: The placozoan cox1 single base pair exon. [PDF]
PLoS ONE, 2017 The phylum Placozoa holds a key position for our understanding of the evolution of mitochondrial genomes in Metazoa. Placozoans possess large mitochondrial genomes which harbor several remarkable characteristics such as a fragmented cox1 gene and trans ...
Hans-Jürgen Osigus +2 more
doaj +2 more sources
Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis [PDF]
Microbial Cell, 2016 Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth ...
R. Dela Cruz, Mi-Young Jeong, D. Winge
semanticscholar +4 more sources
A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria
Journal of Biological Chemistry, 2016 Cytochrome c oxidase assembly requires the synthesis of the mitochondria-encoded core subunits, Cox1, Cox2, and Cox3. In yeast, Pet54 protein is required to activate translation of the COX3 mRNA and to process the aI5β intron on the COX1 transcript. Here
Angelica Zamudio-Ochoa +2 more
exaly +2 more sources
Cell Reports, 2015 Cytochrome c oxidase, the terminal enzyme of the respiratory chain, is assembled from mitochondria- and nuclear-encoded subunits. The MITRAC complex represents the central assembly intermediate during this process as it receives imported subunits and ...
Sven Dennerlein +2 more
exaly +2 more sources
The fission yeast Schizosaccharomyces pombe Mtf2 is required for mitochondrial cox1 gene expression.
Microbiology, 2018 Mitochondrial gene expression is essential for adenosine triphosphate synthesis via oxidative phosphorylation, which is the universal energy currency of cells. Here, we report the identification and characterization of a homologue of Saccharomyces cerevisiae Mtf2 (also called Nam1) in Schizosaccharomyces pombe.
Jinyu Liu +6 more
semanticscholar +3 more sources
Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice
Inflammation Research, 2017 Alzheimer's disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain. We investigated the possible neuroprotective role of flavocoxid, a dual inhibitor of cyclooxygenases-1/2 (COX-1/2) and 5-Lipoxygenase (5-LOX), in triple-transgenic (3xTg-AD) mice.Mice were 3 months at the beginning of the study ...
A. Bitto +12 more
semanticscholar +4 more sources