Results 11 to 20 of about 26,419 (235)
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox [PDF]
Circulation Research, 2019 Rationale: Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A 2 , both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate any antithrombotic role for COX1-derived prostacyclin from ...
Mitchell, Jane A +8 more
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Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis [PDF]
Microbial Cell, 2016 Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth defect in cox23∆ yeast cells.
Richard Dela Cruz +2 more
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Defective COX1 expression in aging mice liver
Biology Open, 2023 ABSTRACT Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild mitochondrial dysfunctions appear to be associated with longer lifespans.
Steffen Witte +5 more
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An Ancient Fission of Mitochondrial cox1 [PDF]
Molecular Biology and Evolution, 2009 Many genes inherited from the alpha-proteobacterial ancestor of mitochondria have undergone evolutionary transfer to the nuclear genome in eukaryotes. In some rare cases, genes have been functionally transferred in pieces, resulting in split proteins that presumably interact in trans within mitochondria, fulfilling the same role as the ancestral ...
Ryan M R, Gawryluk, Michael W, Gray
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Swarms of diversity at the gene cox1 in Antarctic krill [PDF]
Heredity, 2010 The Antarctic krill, Euphausia superba, is an abundant and key species found in the Southern Ocean that forms dense, discrete swarms. Despite over three decades of research on Antarctic krill, the genetics of individual swarms is yet to be specifically investigated.
Goodall-Copestake, WP +5 more
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Molecular and biochemical analysis of Saccharomyces cerevisiae cox1 mutants [PDF]
Current Genetics, 1998 We report on the molecular and biochemical analysis of a set of 13 respiratory deficient mutants of Saccharomyces cerevisiae which are specifically altered in COX1, the gene encoding the subunit Cox1p of cytochrome c oxidase. DNA sequence analysis shows that three are due to frameshift mutations, two to nonsense mutations, and eight to missense ...
Lemaire, C., Robineau, S., Netter, P.
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COX24 Codes for a Mitochondrial Protein Required for Processing of the COX1 Transcript [PDF]
Journal of Biological Chemistry, 2006 In most strains of Saccharomyces cerevisiae the mitochondrial gene COX1, for subunit 1 of cytochrome oxidase, contains multiple exons and introns. Processing of COX1 primary transcript requires accessory proteins factors, some of which are encoded by nuclear genes and others by reading frames residing in some of the introns of the COX1 and COB genes ...
Barros, Mario H. +3 more
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Cyclooxygenase 1(COX1) polymorphisms in African-American and caucasian populations [PDF]
Human Mutation, 2002 Cyclooxygenases (COXs) are the primary targets of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), and thus enzymes of major interest to pharmacology, pharmacogenetics, and epidemiology. Genetic variants that affect enzyme function, or the interaction with NSAIDs, could alter drug response.
Cornelia M, Ulrich +6 more
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Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance [PDF]
Journal of Cell Science, 2015 Mitochondria provide the main portion of cellular energy in form of ATP produced by the F1Fo ATP synthase, which uses the electrochemical gradient, generated by the mitochondrial respiratory chain (MRC). In human mitochondria, the MRC is composed of four multisubunit enzyme complexes, with the cytochrome c oxidase (COX, also known as complex IV) as the
S. Dennerlein, P. Rehling
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